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Abstract
Sera from patients with infectious mononucleosis contain antibodies against red cells
of sheep, horse, ox, and rabbit and against human red cells treated with Newcastle
disease virus. These antibodies have been examined by various immunochemical techniques
and all found to consist almost entirely of γ1M-globulin (19S). Cross absorption and elution experiments suggest that the rabbit
cell antibody is separate from the other systems. The Newcastle agglutinin is probably
also separate. Antibodies against sheep, horse, and ox cells show a well-defined pattern
of cross-absorption, and it is suggested either that these antibodies are separate
globulins with similar but nonidentical combining sites which react with similar but
nonidentical receptors on sheep, horse, and ox red cells, or that several unrelated
antibodies in the sera of patients with infectious mononucleosis react with different
and unrelated antigenic determinants shared by heterologous red cells.
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Article info
Publication history
Accepted:
June 30,
1964
Received:
February 17,
1964
Footnotes
☆The Newcastle disease virus was supplied by Dr. A. Isaacs of the Institute for Medical Research, Mill Hill, London, England.
Identification
Copyright
© 1964 Published by Elsevier Inc.