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Sera from patients with infectious mononucleosis contain antibodies against red cells of sheep, horse, ox, and rabbit and against human red cells treated with Newcastle disease virus. These antibodies have been examined by various immunochemical techniques and all found to consist almost entirely of γ1M-globulin (19S). Cross absorption and elution experiments suggest that the rabbit cell antibody is separate from the other systems. The Newcastle agglutinin is probably also separate. Antibodies against sheep, horse, and ox cells show a well-defined pattern of cross-absorption, and it is suggested either that these antibodies are separate globulins with similar but nonidentical combining sites which react with similar but nonidentical receptors on sheep, horse, and ox red cells, or that several unrelated antibodies in the sera of patients with infectious mononucleosis react with different and unrelated antigenic determinants shared by heterologous red cells.
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Accepted: June 30, 1964
Received: February 17, 1964
☆The Newcastle disease virus was supplied by Dr. A. Isaacs of the Institute for Medical Research, Mill Hill, London, England.
© 1964 Published by Elsevier Inc.