This paper is only available as a PDF. To read, Please Download here.
The addition of ADP to native platelet-rich plasma causes platelet aggregation and acceleration of clotting. Addition of ADP to platelet-poor plasma does not accelerate clotting. The evidence suggests that the accelerating effect of ADP on clotting in platelet-rich plasma is associated with release of clotting activity from platelets. Addition of AMP or adenosine to native platelet-rich plasma in concentrations which prevent platelet aggregation does not inhibit clotting. However, this does prevent the acceleration of clotting induced by ADP. Concentrations of ADP which inhibit clotting are more than 10,000 times that required to initiate platelet aggregation. Heparin readily prevents thrombin-induced platelet aggregation but does not, in usual concentrations, inhibit platelet aggregation by ADP. However, heparin prevents the acceleration of clotting by ADP in platelet-rich plasma. These observations show that while platelet aggregation and clotting are closely related they can be separated from each other in native plasma.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Translational Research
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The Adhesiveness of Human Blood Platelets in Vitro.Thesis, Scandinav. J. Clin. & Lab. Invest. 1960; 12
- Macroscopic Studies of Platelet Aggregation. Nature of an Aggregating Factor in Red Blood Cells and Platelets.Thromb. et Diath. Haemorrh. 1961; 6: 86
- Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets.Nature. 1961; 192: 531
- Aggregation of Blood Platelets by Adenosine Diphosphate and Its Reversal.Nature. 1962; 194: 927
- Platelet Aggregation. I. Some Effects of the Adenosine Phosphates, Thrombin, and Cocaine Upon Platelet Adhesiveness.J. Clin. Path. 1962; 15: 446
- Platelet Clumping in Vivo.Nature. 1963; 197: 1019
- Adenosine Triphosphate: An Inhibitor of Generation of Thrombo plastin.Nature. 1963; 199: 708
- Anticoagulant Action of Adenosine Triphosphate.Nature. 1963; 200: 469
- Anticoagulant Action of Adenosine Di- and Triphosphate (ADP and ATP).in: ed. 2. Fed. Proc. 23. 1964: 299
- Some Properties of the Platelet Connective Tissue Mixed Agglutination Reaction.in: ed. 2. Proc. Soc. Exper. Biol. & Med. III. 1962: 292
- Platelet Aggregation. II. Some Results From a New Method of Study.J. Clin. Path. 1962; 15: 452
- An Attempt to Identify a Single Phospholipid Active in Blood Coagulation.Brit. J. Haemat. 1957; 3: 387
- Mechanism of Action of Thrombin on Platelets.J. Clin. Invest. 1962; 41: 543
- The Mechanism of Platelet Aggregation in Relation to Hemostasis.Thromb. et Diath. Haemorrh. 1962; 7: 480
Accepted: June 20, 1964
Received: April 23, 1964
☆This work was supported by grants from the Medical Research Council, the Ontario Heart Foundation, and the National Institutes of Health, United States Public Health Service, H-6912 and H-6951.
© 1964 Published by Elsevier Inc.