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Abstract
The addition of ADP to native platelet-rich plasma causes platelet aggregation and
acceleration of clotting. Addition of ADP to platelet-poor plasma does not accelerate
clotting. The evidence suggests that the accelerating effect of ADP on clotting in
platelet-rich plasma is associated with release of clotting activity from platelets.
Addition of AMP or adenosine to native platelet-rich plasma in concentrations which
prevent platelet aggregation does not inhibit clotting. However, this does prevent
the acceleration of clotting induced by ADP. Concentrations of ADP which inhibit clotting
are more than 10,000 times that required to initiate platelet aggregation. Heparin
readily prevents thrombin-induced platelet aggregation but does not, in usual concentrations,
inhibit platelet aggregation by ADP. However, heparin prevents the acceleration of
clotting by ADP in platelet-rich plasma. These observations show that while platelet
aggregation and clotting are closely related they can be separated from each other
in native plasma.
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Article info
Publication history
Accepted:
June 20,
1964
Received:
April 23,
1964
Footnotes
☆This work was supported by grants from the Medical Research Council, the Ontario Heart Foundation, and the National Institutes of Health, United States Public Health Service, H-6912 and H-6951.
Identification
Copyright
© 1964 Published by Elsevier Inc.
