Research Article| Volume 64, ISSUE 4, P581-593, October 1964

Fucose and agglutinogen contents of urine from patients with duodenal ulcers

      This paper is only available as a PDF. To read, Please Download here.


      Urine specimens from “secretors” of blood groups A and O contain small amounts of nonultrafiltrable A and H activity. Lea activity, however, is found in much the same titer as in saliva, “nonsecretors” having a considerably higher titer than “secretors.” This Lea activity of urine is ultrafiltrable. Almost all the fucose in urine is ultrafiltrable, and “secretors” have a higher value than “nonsecretors.” In a given phenotypic class, the ratio of urinary fucose concentration to urinary creatinine concentration remains constant at varying creatinine concentrations, suggesting that the fucose-containing molecules are derived from the plasma and are not produced in the urinary tract. This ratio is much higher in “secretors” than in “nonsecretors.” Small molecules containing fucose would seem to be the end products of blood group substance metabolism, and the degradation products of A and H lose their serologic activity, while those of Lea retain their activity in an ultrafiltrable molecule. The Lea molecule in the urine of “nonsecretors” can become attached to the surface of erythrocytes from “secretors.” No differences were found between the urine of duodenal ulcer patients and that of normal control subjects.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Schiff F.
        • Sasaki H.
        Der Ausscheidungstypus ein auf serologischen Wege nachweisbares mendelndes Merkmal.
        Klin. Wchnschr. 1932; 11: 1426
        • Levine P.
        • Robinson E.
        • Celano M.
        • Briggs O.
        • Falkinburg L.
        Gene Interaction Resulting in Suppression of Blood Group Substance B.
        Blood. 1955; 10: 1100
        • Grubb R.
        Correlation Between Lewis Blood Group and Secretor Character in Man.
        Nature. 1948; 162: 933
        • Ceppellini R.
        Nuova interpretazione sulla genetica dei caratteri Lewis eritrocitari e salivari derivante dall'analisis di 87 famiglie.
        Suppl. Ric. Sc. 1955; 25: 3
        • Grubb R.
        Observations on the Human Group System Lewis.
        Acta path. et microbiol. scandinav. 1951; 28: 61
        • Roberts J.A.F.
        Blood Groups and Susceptibility to Disease.
        Brit. J. Prev. Soc. Med. 1957; 11: 107
        • Clarke C.A.
        • Edwards J.W.
        • Haddock D.R.W.
        • Howel-Evans A.W.
        • McConnell R.B.
        • Sheppard P.M.
        ABO Blood Groups and Secretor Character in Duodenal Ulcer.
        Brit. M. J. 1956; 2: 725
        • Wallace J.
        • Peebles Brown D.A.
        • Cook I.A.
        • Melrose A.G.
        The Secretor Status in Duodenal Ulcer.
        Scottish M. J. 1958; 3: 105
        • McConnell R.B.
        Associations and Linkage in Human Genetics.
        Am. J. Med. 1963; 34: 692
        • Aminoff D.
        • Morgan W.T.J.
        • Watkins W.M.
        Studies in Immunochemistry; Isolation and Properties of the Human Blood Group A Substance.
        Biochem. J. 1950; 46: 426
        • Annison E.F.
        • Morgan W.T.J.
        Studies in Immunochemistry; Isolation and Properties of Lewis (Lea) Human Blood-Group Substance.
        Biochem. J. 1952; 50: 460
        • Annison E.F.
        • Morgan W.T.J.
        Studies in Immunochemistry; Isolation and Properties of Human Blood-Group H Substance.
        Biochem. J. 1952; 52: 247
        • Gibbons R.A.
        • Morgan W.T.J.
        Studies in Immunochemistry; Isolation and Properties of Substances of Human Origin Possessing Blood-Group B Specificity.
        Biochem. J. 1954; 57: 283
        • Morgan W.T.J.
        A Contribution to Human Biochemical Genetics; The Chemical Basis of Blood-Group Specificity.
        in: ed. 4. Proc. Roy. Soc. s.B. 151. 1960: 308
        • Berggard I.
        Proteins, Glycoproteins, and Mucopolysaccharides in Normal Human Urine. I. Fractionation of Non-Dialysable Materials by Ultrafiltration and by Zone Electro-phoresis.
        Arkiv Kemi. 1961; 18: 291
        • Berggard I.
        Proteins, Glycoproteins, and Mucopolysaccharides in Normal Human Urine. II. Further Zone Electrophoretic Studies on Nonultrafiltrable Materials.
        Arkiv Kemi. 1961; 18: 315
        • Bourrillon R.
        • Cornillot P.
        • Got R.
        Les glycoproteines de l'urine humaine normale. IV. Fractionnement et caractérisation des glycopeptides urinaires.
        Clin. chim. acta. 1962; 7: 506
        • Hartmann G.
        Group Antigens in Human Organs.
        Ejnar Munksgaards Forlag, Copenhagen1941
        • King Jr., J.S.
        • Boyce W.H.
        High Molecular Weight Substances in Human Urine.
        Charles C Thomas, Publisher, Springfield, Ill1963 (chap. 13)
        • White A.A.
        • Hess W.C.
        Paper Chromatographic Detection of Sugars in Normal and Dystrophic Human Urines.
        Arch. Biochem. & Biophys. 1956; 64: 57
        • Jusic D.
        • Fisher-Herman M.
        Identification of Sugars in Urine by Electrophoresis on Paper.
        Clin. chim. acta. 1961; 6: 472
        • Dische Z.
        • Shettles L.B.
        A Specific Color Reaction of Methylpentoses and a Spectrophotometric Micromethod for Their Determination.
        J. Biol. Chem. 1948; 175: 595
        • Dische Z.
        New Color Reactions for Determination of Sugars in Polysaccharides.
        in: ed. 4. Methods of Biochemical Analysis. vol. 2. Interscience Publishers, Inc, New York1955
        • McConnell R.B.
        Lewis Blood Group Substances in Body Fluids.
        in: Proc. Second Internat. Congress of Human Genetics. 1961: 858
        • Evans D.A.P.
        The Fucose and Agglutinogen Contents of Saliva in Subjects With Duodenal Ulcers.
        J. Lab. & Clin. Med. 1960; 55: 386
        • Evans D.A.P.
        • McConnell R.B.
        • Donohoe W.T.A.
        • Sircus W.
        • Crean G.P.
        Fucose and Agglutinogen Contents of Gastric Juice in Subjects With Peptic Ulcers.
        J. Lab. & Clin. Med. 1963; 61: 660
        • Boyd W.C.
        • Shapleigh E.
        Separation of Individuals of any Blood Group Into Secretors and Nonsecretors by Use of a Plant Agglutinin (Lectin).
        Blood. 1954; 9: 1195
        • Race R.R.
        • Sanger R.
        Blood Groups in Man.
        in: ed. 4. Blackwell, Oxford1962: 233
        • Lawler S.D.
        • Lawler L.J.
        Human Blood Groups and Inheritance.
        ed. 2. William Heinemann Ltd, London1957 (chap. 2)
        • King E.J.
        • Wooton I.D.P.
        Micro-analysis in Medical Biochemistry.
        in: ed. 3. Churchill, London1956: 161
        • Bailey N.T.J.
        Statistical Methods in Biology.
        The English Universities Press Ltd, London1959
        • Scheffe H.
        A Method for Judging All Contrasts in the Analysis of Variance.
        Biometrika. 1953; 40: 87
        • King Jr., J.S.
        • Fielden M.L.
        • Goodman H.O.
        • Boyce W.H.
        Total Nondialysable Solids in Human Urine. X. Isolation and Characterisation of Nonultrafiltrable Material With Blood-Group Substance Activity.
        Arch. Biochem. & Biophys. 1961; 95: 310
        • Watkins W.M.
        Blutgruppenantigene von Erythrozyten.
        Deutsch. Med. Wchnschr. 1963; 88 (quoted in Uhlenbruck, G.): 143
        • Witebsky E.
        • Neter E.
        The Distribution of Blood Group Properties and Blood Group Property Destroying Factors in the Intestinal Tract of Man.
        J. Exper. Med. 1935; 62: 589
        • Watkins W.M.
        • Morgan W.T.J.
        Specific Inhibition Studies Relating to the Lewis Blood-Group System.
        Nature. 1957; 180: 1038
        • Sneath J.S.
        • Sneath P.H.A.
        Transformation of the Lewis Groups of Human Red Cells.
        Nature. 1955; 176: 172
        • Mollison P.L.
        • Polley M.J.
        • Crome P.
        Temporary Suppression of Lewis Blood-Group Antibodies to Permit Incompatible Transfusion.
        Lancet. 1963; 1: 909