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Research Article| Volume 64, ISSUE 4, P581-593, October 1964

Fucose and agglutinogen contents of urine from patients with duodenal ulcers

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      Abstract

      Urine specimens from “secretors” of blood groups A and O contain small amounts of nonultrafiltrable A and H activity. Lea activity, however, is found in much the same titer as in saliva, “nonsecretors” having a considerably higher titer than “secretors.” This Lea activity of urine is ultrafiltrable. Almost all the fucose in urine is ultrafiltrable, and “secretors” have a higher value than “nonsecretors.” In a given phenotypic class, the ratio of urinary fucose concentration to urinary creatinine concentration remains constant at varying creatinine concentrations, suggesting that the fucose-containing molecules are derived from the plasma and are not produced in the urinary tract. This ratio is much higher in “secretors” than in “nonsecretors.” Small molecules containing fucose would seem to be the end products of blood group substance metabolism, and the degradation products of A and H lose their serologic activity, while those of Lea retain their activity in an ultrafiltrable molecule. The Lea molecule in the urine of “nonsecretors” can become attached to the surface of erythrocytes from “secretors.” No differences were found between the urine of duodenal ulcer patients and that of normal control subjects.
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