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Packed red cells, obtained by centrifugation at 15,000 g, were studied by means of a rotational concentric viscometer. Viscosities of packed cells containing S-S hemoglobin were higher than viscosities of the corresponding systems containing A-A or S-A hemoglobins. Sickling of cells, induced by a reduction of S-S hemoglobin with carbon dioxide, resulted in elevated blood viscosity and an increase in the packed cell viscosity. The latter was found to be from two hundred to one thousand fold higher than in the systems containing normal(Hb A-A) cells. For comparison, crenated hemoglobin A-A cells and hemoglobin A-A cells treated with formalin were also studied. Certain deductions were made with respect to the internal fluidity and the internal molecular architecture of the red cells. The relevance of these parameters to circulation is discussed.
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Accepted: July 16, 1964
Received: May 25, 1964
☆Supported by a grant from the National Heart Foundation of Australia.
© 1964 Published by Elsevier Inc.