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Abstract
Packed red cells, obtained by centrifugation at 15,000 g, were studied by means of
a rotational concentric viscometer. Viscosities of packed cells containing S-S hemoglobin
were higher than viscosities of the corresponding systems containing A-A or S-A hemoglobins.
Sickling of cells, induced by a reduction of S-S hemoglobin with carbon dioxide, resulted
in elevated blood viscosity and an increase in the packed cell viscosity. The latter
was found to be from two hundred to one thousand fold higher than in the systems containing
normal(Hb A-A) cells. For comparison, crenated hemoglobin A-A cells and hemoglobin
A-A cells treated with formalin were also studied. Certain deductions were made with
respect to the internal fluidity and the internal molecular architecture of the red
cells. The relevance of these parameters to circulation is discussed.
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References
- Cardiovascular Findings in Patients With Sickle Cell Anaemia.Am. J. Cardiol. 1964; 13: 320
- Sickle Cell Anemia Simulating Coronary Occlusion.Ann. Int. Med. 1944; 21: 1045
- Vascular Occlusion and Ischemia Infarction in Sickle Cell Disease.Am. J. Med. Sc. 1948; 216: 11
- Sickle Cell Trait and Superior, Longitudinal Sinus Thrombosis.Ann. Int. Med. 1964; 60: 465
- Massive Intravascular Sickling After Exchange Transfusion With Sickle Cell Trait Blood.Transfusion. 1963; 3: 387
- Failure of Carbonmonoxy Sickle Cell Haemoglobin to Alter the Sickle State.Lancet. 1964; 1: 79
- Electron Microscopy of Sickle Hemoglobin Gels.in: Abst. 47th Meeting, Atlantic Cityed. 5. Fed. Proc. 22. 1963: 601
- A Sub-molecular Mechanism of Gel Formation in Sickle Cell Haemolysate.Nature. 1962; 194: 933
- Hemolysis and Related Phenomena.in: J. & A. Churchill, Ltd, London1948: 145
- An Application of a Cone-in-Cone Viscometer to the Study of Viscosity, Thixotropy, and Clotting of Blood.Biorheology. 1963; 1: 91
- Viscosity and Clotting of Blood in Venous Thrombosis and Coronary Occlusion.Circulation Res. 1964; 14: 1
- The Principle of Rheometry.in: ed. 5. Rheology. vol. 3. Academic Press, Inc, New York1960: 18
- Considerations of the Internal Viscosity of Red Cells and Its Effect on the Viscosity of Whole Blood.Angiology. 1962; 13: 333
- Verminderte Erythrocytenflexibilität (herforgerufen durch Barbiturate, Verbrennungen, Hypoxämien) und ihre Wirkung auf den Capillarkreislau.Pflügers Archiv. 1963; 278: 130
- Structure of Haemoglobin.Nature. 1963; 199: 633
Article info
Publication history
Accepted:
July 16,
1964
Received:
May 25,
1964
Footnotes
☆Supported by a grant from the National Heart Foundation of Australia.
Identification
Copyright
© 1964 Published by Elsevier Inc.
