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Research Article| Volume 64, ISSUE 4, P624-633, October 1964

Direct effects of vasoactive agents on segmental resistance of the mesenteric and portal circulation

Studies with 1-epinephrine, levarterenol, angiotensin, vasopressin, acetylcholine, methacholine, histamine, and serotonin
  • E.Clinton Texter Jr.
    Affiliations
    From the Medical Service, Veterans Administration Research Hospital, Passavant Memorial Hospital Chicago, Ill., USA

    From the Department of Medicine, Northwestern University Medical School Chicago, Ill., USA
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  • Ching-Chung Chou
    Affiliations
    From the Medical Service, Veterans Administration Research Hospital, Passavant Memorial Hospital Chicago, Ill., USA

    From the Department of Medicine, Northwestern University Medical School Chicago, Ill., USA
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  • Steven L. Merrill
    Affiliations
    From the Medical Service, Veterans Administration Research Hospital, Passavant Memorial Hospital Chicago, Ill., USA

    From the Department of Medicine, Northwestern University Medical School Chicago, Ill., USA
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  • Higino C. Laureta
    Affiliations
    From the Medical Service, Veterans Administration Research Hospital, Passavant Memorial Hospital Chicago, Ill., USA

    From the Department of Medicine, Northwestern University Medical School Chicago, Ill., USA
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  • Edward D. Frohlich
    Affiliations
    From the Medical Service, Veterans Administration Research Hospital, Passavant Memorial Hospital Chicago, Ill., USA

    From the Department of Medicine, Northwestern University Medical School Chicago, Ill., USA
    Search for articles by this author
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      Abstract

      The direct effects of l-epinephrine, levarterenol, angiotensin, vasopressin, acetylcholine, serotonin, histamine, and methacholine on the segmental resistance of the mesenteric and portal circulations of dogs were studied by intra-arterial infusion into the perfused superior mesenteric artery. Ten studies were carried out with each agent in a total of 78 dogs. The control resistance was low in comparison to other vascular beds. The mesenteric vasculature was more sensitive to vasoconstrictor than to vasodilator substances. Vasopressin and angiotensin were the most potent constrictors. The major increase in resistance was localized to the small vessel segment. Acetylcholine and histamine were the most active of the vasodilators. Total and small vessel resistance decreased equally with acetylcholine; histamine decreased small vessel resistance. Venoconstriction was observed with levarterenol and epinephrine; the remaining substances did not significantly alter venous resistance. The relationship of these observations to the dynamics of the mesenteric and portal circulations is discussed.
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