Research Article| Volume 64, ISSUE 4, P675-684, October 1964

Organic phosphate compounds of erythrocytes from individuals with uremia

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      The concentrations of phosphorylated carbohydrate intermediates in erythrocytes from patients with uremia were determined by anion exchange analysis. The elevated values for organic phosphate in freshly drawn blood could be accounted for almost entirely by the 2,3-diphosphoglycerate and adenosine triphosphate present. The hexose diphosphate and guanosine triphosphate concentrations were slightly elevated. When these blood samples were stored at 4 °C. for 14 and 21 days, the 2,3-diphosphoglycerate, adenosine triphosphate, hexose diphosphate, and guanosine triphosphate concentrations were greater than those for stored erythrocytes from healthy individuals. After extracorporeal hemodialysis of a patient with uremia, the elevated predialysis concentrations of these phosphorylated compounds decreased.
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