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Abstract
The concentrations of phosphorylated carbohydrate intermediates in erythrocytes from
patients with uremia were determined by anion exchange analysis. The elevated values
for organic phosphate in freshly drawn blood could be accounted for almost entirely
by the 2,3-diphosphoglycerate and adenosine triphosphate present. The hexose diphosphate
and guanosine triphosphate concentrations were slightly elevated. When these blood
samples were stored at 4 °C. for 14 and 21 days, the 2,3-diphosphoglycerate, adenosine
triphosphate, hexose diphosphate, and guanosine triphosphate concentrations were greater
than those for stored erythrocytes from healthy individuals. After extracorporeal
hemodialysis of a patient with uremia, the elevated predialysis concentrations of
these phosphorylated compounds decreased.
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Article info
Publication history
Accepted:
July 27,
1964
Received:
April 20,
1964
Footnotes
☆This investigation was supported by United States Public Health Service Grant No. HE-05716 from the National Institutes of Health, Bethesda, Md.
Identification
Copyright
© 1964 Published by Elsevier Inc.