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Activation of Hageman factor by solutions of ellagic acid

  • Oscar D. Ratnoff
    Footnotes
    Affiliations
    From the Department of Medicine, School of Medicine, Cleveland, Ohio USA

    From the Department of Chemistry, Western Reserve University, Cleveland, Ohio USA

    From the Department of Chemistry, University Hospitals of Cleveland Cleveland, Ohio USA
    Search for articles by this author
  • James D. Crum
    Affiliations
    From the Department of Medicine, School of Medicine, Cleveland, Ohio USA

    From the Department of Chemistry, Western Reserve University, Cleveland, Ohio USA

    From the Department of Chemistry, University Hospitals of Cleveland Cleveland, Ohio USA
    Search for articles by this author
  • Author Footnotes
    ∗ Career Investigator of the American Heart Association.
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      Abstract

      Aged solutions of tannic acid and of certain o-dihydroxyl compounds similar in structure to its gallic acid moiety accelerated clotting. One of many compounds tested, ellagic acid (4,4′,5,5′,6,6′-hexahydroxydiphenic acid 2,6:2′,6′-dilactone), at concentrations as low as 10−8M, accelerated clotting and appeared to activate Hageman factor in a manner analogous to that of glass surfaces. The chemical nature of the action of ellagic acid was not elucidated but seemed to be related to the presence of o-dihydroxyl groups in its molecule.
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