Effects of carbon tetrachloride poisoning on the plasma levels of cytoplasmic and mitochondrial enzymes in animals with nutritional fatty metamorphosis

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      The plasma levels of glutamic-oxalacetic (GOT) and glutamic-pyruvic transaminase (GPT), lactic dehydrogenase (LD), aldolase (ALD), phosphohexoisomerase (PHI), malic dehydrogenase (MD), isocitric dehydrogenase (ICD), glutathione reductase (GR), glutamic dehydrogenase (GD), and glucose-6-phosphatase (G-6-P) were studied in animals with nutritional fatty metamorphosis, with and without the intraperitoneal administration of carbon tetrachloride. There was no difference between the values of these enzymes in rats with nutritional fatty metamorphosis and of those in animals taking a normal diet. Small doses of carbon tetrachloride caused a greater rise of the levels of all 10 enzymes and larger doses caused a greater rise of most of the enzymes in the high-fat, low-choline fed animals than in those taking a normal diet. At high doses of carbon tetrachloride, however, there were no significant differences in the plasma levels of GPT and ALD of the two groups of animals. The rate of increase of the plasma levels of the enzymes appeared to be slower in animals with nutritional fatty metamorphosis than in those on normal diets, at all doses of carbon tetrachloride.
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