Advertisement

Significance of lactase deficit in ulcerative colitis

  • Allan B. Cady
    Footnotes
    Affiliations
    From the Gastroenterology Section, Veterans Administration Hospital, Hines, Illinois, U.S.A.

    From the Department of Medicine, University of Illinois College of Medicine Chicago, Ill., U.S.A.

    From the Department of Biochemistry, Chicago Medical School Chicago, Ill., U.S.A.
    Search for articles by this author
  • James B. Rhodes
    Footnotes
    Affiliations
    From the Gastroenterology Section, Veterans Administration Hospital, Hines, Illinois, U.S.A.

    From the Department of Medicine, University of Illinois College of Medicine Chicago, Ill., U.S.A.

    From the Department of Biochemistry, Chicago Medical School Chicago, Ill., U.S.A.
    Search for articles by this author
  • Armand Littman
    Correspondence
    Reprint requests: Veterans Administration Hospital, Hines, Ill.
    Affiliations
    From the Gastroenterology Section, Veterans Administration Hospital, Hines, Illinois, U.S.A.

    From the Department of Medicine, University of Illinois College of Medicine Chicago, Ill., U.S.A.

    From the Department of Biochemistry, Chicago Medical School Chicago, Ill., U.S.A.
    Search for articles by this author
  • Robert K. Crane
    Footnotes
    Affiliations
    From the Gastroenterology Section, Veterans Administration Hospital, Hines, Illinois, U.S.A.

    From the Department of Medicine, University of Illinois College of Medicine Chicago, Ill., U.S.A.

    From the Department of Biochemistry, Chicago Medical School Chicago, Ill., U.S.A.
    Search for articles by this author
  • Author Footnotes
    ∗ Present address: A. H. Robins Co., Richmond, Va.
    ∗∗ Present address: Department of Medicine, University of Kansas, Kansas City, Kan.
    ∗∗∗∗ Present address: Department of Physiology, Rutgers Medical School, New Brunswick, N. J.
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Disaccharidase assays on biopsies of the small intestine from 32 male patients with ulcerative colitis revealed lactase deficiency in 46 per cent of them, a significantly higher incidence than in control patients. Flat blood sugar curves and diarrhea occurred with 100 Gm. lactose tolerance tests in the patients with low intestinal lactase values; normal curves and no diarrhea were the usual result with normal lactase. All 6 patients in the first year of symptoms had a lactase deficit. With repeated biopsies, lactase rose in 3 patients with clinical improvement and decreased in 2 in whom symptoms became worse. In double blind feeding trials with 50 or 100 Gm. of sugar daily in 18 patients, lactose did not increase symptoms more frequently than glucose. The occurrence of symptoms during the feeding of sugar was not influenced by the presence or absence of lactase deficit.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Wright K.
        • Truelove S.C.
        A controlled therapeutic trial of various diets in ulcerative colitis.
        Brit. M. J. 1965; 2: 138
        • Wright R.
        • Truelove S.C.
        Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets.
        Am. J. Digest. Dis. 1966; 11: 847
        • Binder H.J.
        • Gryboski J.P.
        • Thayer Jr., W.R.
        • Spiro H.M.
        Intolerance to milk in ulcerative colitis: A preliminary report.
        Am. J. Digest. Dis. 1966; 11: 858
        • Dahlqvist A.
        Method for assay of intestinal disaccharidases.
        Anal. Biochem. 1964; 7: 18
        • Dunphy J.V.
        • Littman A.
        • Hammond J.B.
        • Forstner G.
        • Dahlqvist A.
        • Crane R.K.
        Intestinal lactase deficit in adults.
        Gastroenterology. 1965; 49: 12
        • Littman A.
        • Hammond J.B.
        Diarrhea in adults caused by deficiency in intestinal disaccharidases.
        Gastroenterology. 1965; 48: 237
        • Cady A.B.
        • Rhodes J.B.
        • Littman A.
        • Crane R.K.
        Lactase deficit in ulcerative colitis and regional enteritis.
        Gastroenterology. 1965; 48: 808
        • Struthers Jr., J.E.
        • Singleton J.W.
        • Kern Jr., F.
        Intestinal lactase deficiency in ulcerative colitis and regional ileitis.
        Ann. Int. Med. 1965; 63: 221
        • Cook G.C.
        • Kajubi S.K.
        Tribal incidence of lactase deficiency in Uganda.
        Lancet. 1966; 1: 725
        • Bayless T.M.
        • Rosensweig N.S.
        Race and incidence of lactase deficiency.
        J. A. M. A. 1966; 197: 968
        • Frazer A.C.
        • Hood C.
        • Davies A.G.
        • Carter P.A.
        • Montgomery R.D.
        • Schneider R.
        • Goodhart J.
        Carbohydrate intolerance in ulcerative colitis.
        Lancet. 1966; 1: 503
        • Littman A.
        Isolated lactase deficit in the adult: A present view.
        J. A. M. A. 1966; 195: 954