Research Article| Volume 70, ISSUE 1, P1-8, July 1967

The selective activity of lysostaphin in vivo

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      Thirty-two nasal carriers of Staphylococcus aureus were treated for 7 to 12 days with intranasal lysostaphin. The in vivo response to therapy paralleled the in vitro susceptibility of the organisms to lysostaphin. There was marked reduction in the numbers of S. aureus with a smaller decrease in the numbers of S. albus and no reduction in the numbers of diphtheroids. Reacquisition of coagulase-positive staphylococci was significantly less rapid in subjects with larger numbers of diphtheroids remaining in the nose after therapy than in subjects with smaller numbers of residual flora. Thus, the selective activity of lysostaphin permitted the demonstration of bacterial interference by other strains against recolonization by coagulase-positive staphylococci.
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