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Abstract
Thirty-two nasal carriers of Staphylococcus aureus were treated for 7 to 12 days with intranasal lysostaphin. The in vivo response to
therapy paralleled the in vitro susceptibility of the organisms to lysostaphin. There
was marked reduction in the numbers of S. aureus with a smaller decrease in the numbers of S. albus and no reduction in the numbers of diphtheroids. Reacquisition of coagulase-positive
staphylococci was significantly less rapid in subjects with larger numbers of diphtheroids
remaining in the nose after therapy than in subjects with smaller numbers of residual
flora. Thus, the selective activity of lysostaphin permitted the demonstration of
bacterial interference by other strains against recolonization by coagulase-positive
staphylococci.
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References
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Tavormina, P. A.: Mead Johnson Research Center, Personal communication.
Article info
Publication history
Accepted:
February 6,
1967
Received:
September 12,
1966
Footnotes
☆This study was supported by Training Grant T1 AI 267 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Identification
Copyright
© 1967 Published by Elsevier Inc.
