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Adult rats were fed 0.91 mM. (58.3 mg. per kilogram per 24 hours) neomycin in drinking water for 4 weeks, and the dosage was doubled three times at 4 week intervals to a maximum of 7.28 mM. (333.9 mg. per kilogram per 24 hours). No abnormalities were noted in weight gain, in xylose absorption, or in morphology of the small bowel. Animals fed 0.91 mM. neomycin for 1 year showed no change in glucose absorption during perfusion of the small bowel when compared to a control group. However, in animals fed only pellets and water, the addition of neomycin to the perfusate at a level of 1.2 mM. enhanced glucose absorption by 25 to 36 per cent. Increasing the concentration to 6.0 mM. had no effect while 12.0 mM. neomycin reduced glucose absorption by 12 per cent. It is suggested that the discrepant findings of neomycin on absorption are related to dosage and the readily reversible effects on the mucosal cell surface.
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Accepted: February 6, 1967
Received: October 7, 1966
☆Supported by Research Grants T1 AM 5320, National Institute of Arthritis and Metabolic Diseases; CA 02090 and CA 04486, National Cancer Institute; and GMO 9628, National Institute of General Medical Sciences, National Institutes of Health.
© 1967 Published by Elsevier Inc.