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Research Article| Volume 70, ISSUE 1, P9-15, July 1967

Neomycin feeding in the rat: Studies of intestinal absorption of glucose and xylose

  • Selwyn A. Broitman
    Affiliations
    From the Gastroenterology Laboratory, Mallory Institute of Pathology Boston, Mass. U.S.A.

    From the Second and Fourth (Harvard) Medical Services Boston City Hospital Boston, Mass. U.S.A.

    From the Department of Medicine, Harvard Medical School Boston, Mass. U.S.A.

    From the Departments of Microbiology and Pathology, Boston University School of Medicine Boston, Mass. U.S.A.
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  • Dorothy Flint
    Affiliations
    From the Gastroenterology Laboratory, Mallory Institute of Pathology Boston, Mass. U.S.A.

    From the Second and Fourth (Harvard) Medical Services Boston City Hospital Boston, Mass. U.S.A.

    From the Department of Medicine, Harvard Medical School Boston, Mass. U.S.A.

    From the Departments of Microbiology and Pathology, Boston University School of Medicine Boston, Mass. U.S.A.
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  • Norman Zamcheck
    Affiliations
    From the Gastroenterology Laboratory, Mallory Institute of Pathology Boston, Mass. U.S.A.

    From the Second and Fourth (Harvard) Medical Services Boston City Hospital Boston, Mass. U.S.A.

    From the Department of Medicine, Harvard Medical School Boston, Mass. U.S.A.

    From the Departments of Microbiology and Pathology, Boston University School of Medicine Boston, Mass. U.S.A.
    Search for articles by this author
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      Abstract

      Adult rats were fed 0.91 mM. (58.3 mg. per kilogram per 24 hours) neomycin in drinking water for 4 weeks, and the dosage was doubled three times at 4 week intervals to a maximum of 7.28 mM. (333.9 mg. per kilogram per 24 hours). No abnormalities were noted in weight gain, in xylose absorption, or in morphology of the small bowel. Animals fed 0.91 mM. neomycin for 1 year showed no change in glucose absorption during perfusion of the small bowel when compared to a control group. However, in animals fed only pellets and water, the addition of neomycin to the perfusate at a level of 1.2 mM. enhanced glucose absorption by 25 to 36 per cent. Increasing the concentration to 6.0 mM. had no effect while 12.0 mM. neomycin reduced glucose absorption by 12 per cent. It is suggested that the discrepant findings of neomycin on absorption are related to dosage and the readily reversible effects on the mucosal cell surface.
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