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Abstract
Thrombosis is inhibited in heavily reserpinized rabbits. This study was designed to
explain the mechanism of this effect and to see whether it occurred after smaller
doses of reserpine. Platelet adhesiveness, ADP-induced platelet aggregation, and thrombus
propagation were compared in normal and reserpinized animals. Adhesiveness decreased
20 per cent 24 hours after 0.2 mg. reserpine per kilogram was injected intravenously
and 28 per cent after a dose of 0.5 mg. per kilogram. Adhesiveness did not fall in
the first 4 hours after the reserpine injection. The intensity and duration of platelet
aggregation were also impaired in reserpinized animals, and this effect was not reversed
by resuspension of platelets in normal plasma. Thrombus growth was decreased in animals
treated with 0.1 mg. per kilogram reserpine.
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Article info
Publication history
Accepted:
February 13,
1967
Received:
December 19,
1966
Footnotes
☆Partially supported by National Heart Institute Grant HTS 5465, and by Michigan Heart Association Grant “Experimental Thrombosis.”
Identification
Copyright
© 1967 Published by Elsevier Inc.
