Research Article| Volume 70, ISSUE 1, P16-22, July 1967

Download started.


Impairment of platelet function and thrombus growth in reserpine-treated rabbits

      This paper is only available as a PDF. To read, Please Download here.


      Thrombosis is inhibited in heavily reserpinized rabbits. This study was designed to explain the mechanism of this effect and to see whether it occurred after smaller doses of reserpine. Platelet adhesiveness, ADP-induced platelet aggregation, and thrombus propagation were compared in normal and reserpinized animals. Adhesiveness decreased 20 per cent 24 hours after 0.2 mg. reserpine per kilogram was injected intravenously and 28 per cent after a dose of 0.5 mg. per kilogram. Adhesiveness did not fall in the first 4 hours after the reserpine injection. The intensity and duration of platelet aggregation were also impaired in reserpinized animals, and this effect was not reversed by resuspension of platelets in normal plasma. Thrombus growth was decreased in animals treated with 0.1 mg. per kilogram reserpine.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Jaques L.B.
        Spontaneous hemorrhage with anticoagulants.
        Circulation. 1962; 25: 130
        • Salzmann E.
        Effect of reserpine on hemostasis in the rabbit.
        Thromb. et Diath. Haemorrh. 1962; 7: 507
        • Ashwin J.G.
        The effect of drugs on experimental thrombogenesis.
        in: MacMillan L.L. Mustard J.F. Anticoagulants and fibrinolysins. The Macmillan Company, New York1961
        • Zweifler A.J.
        Thrombus propagation in the carotid artery of the rabbit: The effect of malamide and reserpine.
        Circulation. 1963; 27: 829
        • Hellem A.J.
        The adhesiveness of human blood platelets in vitro.
        Scandinav. J. Clin. & Lab. Invest. 1960; 12: 1
        • Brecher G.
        • Cronkite E.P.
        Morphology and enumeration of human blood platelets.
        J. Appl. Physiol. 1950; 3: 365
        • Mustard J.F.
        • Hegardt B.
        • Rowsell H.C.
        • MacMillan R.L.
        Effect of adenosine nucleotides on platelet aggregation and clotting time.
        J. Lab. & Clin. Med. 1964; 64: 548
        • Zweifler A.J.
        • Boddy J.
        Thrombus propagation in the carotid artery of the rabbit.
        Arch. Path. 1965; 80: 636
        • O'Brien J.
        The adhesiveness of native platelets and its prevention.
        J. Clin. Path. 1961; 14: 140
        • O'Brien J.R.
        Platelet aggregation. I. Some effects of adenosine phosphates, thrombin, and cocaine on platelet adhesiveness.
        J. Clin. Path. 1962; 15: 446
        • Hess S.M.
        • Shore P.A.
        • Brodie B.B.
        Persistence of reserpine action after the disappearance of drug from brain: Effect on serotonin.
        J. Pharmacol. & Exper. Therap. 1956; 118: 84
        • Shore P.A.
        • Pletscher A.
        • Tomich E.G.
        • Kuntzman R.
        • Brodie B.B.
        Release of blood platelet serotonin by reserpine and lack of effect on bleeding time.
        J. Pharmacol. & Exper Therap. 1956; 117: 232
        • Mitchell J.R.A.
        • Sharp A.A.
        Platelet clumping in vitro.
        Brit. J. Haemat. 1964; 10: 78
        • Clayton S.
        • Cross M.J.
        The aggregation of blood platelets by catecholamines.
        in: ed. 10. Proc. Physiol. Soc. 27. 1963: 25
        • Honour A.J.
        • Mitchell J.R.A.
        Platelet clumping in vivo.
        Nature. 1963; 197: 1019
      1. Zweifler, A. J.: Unpublished data.

        • Haverback B.J.
        • Dutcher T.F.
        • Shore P.A.
        • Tomich E.G.
        • Terry L.L.
        • Brodie B.B.
        Serotonin changes in platelets and brain induced by small daily doses of reserpine.
        New England J. Med. 1957; 256: 343
        • Sharp A.A.
        Present status of platelet aggregation.
        New England J. Med. 1965; 272: 89
        • Weiner M.
        • Udenfriend S.
        Relationship of platelet serotonin to disturbances of clotting and hemostasis.
        Circulation. 1957; 15: 353
        • Telkka A.
        • Nyholm M.
        • Paasonen M.K.
        Effect of chlorpromazine and reserpine on the blood platelets of rabbits.
        Experientia. 1964; 20: 27