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Research Article| Volume 70, ISSUE 1, P16-22, July 1967

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Impairment of platelet function and thrombus growth in reserpine-treated rabbits

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      Abstract

      Thrombosis is inhibited in heavily reserpinized rabbits. This study was designed to explain the mechanism of this effect and to see whether it occurred after smaller doses of reserpine. Platelet adhesiveness, ADP-induced platelet aggregation, and thrombus propagation were compared in normal and reserpinized animals. Adhesiveness decreased 20 per cent 24 hours after 0.2 mg. reserpine per kilogram was injected intravenously and 28 per cent after a dose of 0.5 mg. per kilogram. Adhesiveness did not fall in the first 4 hours after the reserpine injection. The intensity and duration of platelet aggregation were also impaired in reserpinized animals, and this effect was not reversed by resuspension of platelets in normal plasma. Thrombus growth was decreased in animals treated with 0.1 mg. per kilogram reserpine.
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