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Abstract
Serum levels of monoamine oxidase were determined in 119 adults with acute and chronic
liver disease. Elevated enzyme levels were found in patients with Laennec's cirrhosis,
postnecrotic cirrhosis, and massive neoplastic replacement of the liver, but not during
the acute phases of hepatitis or extrahepatic biliary obstruction. The increased enzyme
activity could not be ascribed to hepatocellular necrosis or dysfunction. Positive
correlations were found between increased enzyme activity and signs of portal hypertension
and portal-systemic collateral circulation. Increased enzyme activity was most closely
associated with hepatic fibrosis and “sinusoidal” hypertension.
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Article info
Publication history
Accepted:
February 18,
1967
Received:
December 27,
1966
Footnotes
☆The opinions contained herein are those of the authors and are not to be construed as official nor as reflecting the views of the United States Public Health Service or of the United States Navy.
Identification
Copyright
© 1967 Published by Elsevier Inc.
