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Hypercupremia in a patient with multiple myeloma

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      Abstract

      The laboratory and clinical investigation of a patient with marked hypercupremia and multiple myeloma is described. The majority of the copper was found to be associated with the IgG myeloma protein. This IgG myeloma protein showed normal immunological reactivity, no significant abnormality in amino acid composition, and no gross increase in copper-binding capacity. Penicillamine therapy did not produce a statistically significant increase in urinary copper excretion.
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