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Abstract
The hemolytic reaction caused by the ingestion of the standard prophylactic antimalarial
dose of primaquine was studied in 3 Caucasian males and 1 Negro male with G-6-PD deficiency.
Each Caucasian subject came from an ethnic group in which primaquine sensitivity is
uncommon (English, Sicilian, Ashkenazic Jewish). In contrast to the mild hemolytic
reaction in the American Negro, destruction of about 20 per cent of circulating red
cells occurred in each Caucasian subject. Hemolysis was similar in these individuals
despite marked differences in clinical and laboratory studies. One subject had enzymatic
studies similar to those observed in G-6-PD deficient Negroes; another had mild but
significant hemolysis before the ingestion of primaquine; and the third failed to
develop clinical jaundice because of accelerated plasma clearance of bilirubin. These
studies suggest that the assay of G-6-PD in hemolysates and even the measurement of
pentose phosphate shunt activity in intact red cells do not provide a basis for the
prediction of the severity of primaquine sensitivity in vivo.
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Article info
Publication history
Accepted:
March 2,
1967
Received:
November 1,
1966
Footnotes
☆Supported by the United States Army Medical Research and Development Command, and by Research Grant AM09307 from the National Institute of Arthritis and Metabolic Diseases.
Identification
Copyright
© 1967 Published by Elsevier Inc.