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Abstract
A total of 113 laboratory workers, whose history of contact with monkeys or monkey
tissues ranged from 0 to 30 years, were tested for herpes simplex virus (HSV) and
B virus (BV) neutralising antibodies. Eighty-three per cent of them were positive
for HSV antibody and 69 per cent were positive for BV antibody. Of the 35 persons
negative for BV antibody, 18 were also negative for HSV antibody. There was no difference
in the rate of either antibody between males and females, but a distinct increase
in the rates and levels of both was noted with increase in age. No significant correlation
could be established between, the rate of presence of BV antibody and duration of
contact with monkeys or their tissues. In only one instance was BV antibody detected,
and that in low level, in a person with no HSV antibody. This man had been working
with monkeys for less than 1 year. In all other cases, BV antibody occurred only when
HSV antibody was also present, and a striking correlation was noted between the levels
of the two antibodies: BV antibody was absent when HSV antibody was absent or had
a geometric mean titer of 1:22; its mean rose to 1:7 when that of HSV was 1:48, and
to 1:24 when that of HSV was 1:88. HSV antibody levels were also higher than those
of BV in 3 of 4 commercial lots of human gamma globulin of placental origin, although
the reverse was true of the fourth lot. The levels of BV antibody of five experimental
lots of gamma globulin from monkeys, prepared by the same procedure and to the same
protein concentration, were comparable to those of gamma globulin from humans. The
implications of these findings with regard to the protection of man against accidental
infection with BV have been discussed.
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Article info
Publication history
Accepted:
March 23,
1967
Received:
February 25,
1967
Identification
Copyright
© 1967 Published by Elsevier Inc.
