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Abstract
In a study involving 37 subjects, whole blood was stored at 4 °C. for 21 and 28 days
in either ACD or CPD anticoagulant, following which, the in vivo viability of the
stored red cells was measured. There was a high degree of correlation (R = 0.95) between
the postinfusion viability of stored cells and poststorage adenosine triphosphate
(ATP) levels. This indicates the potential use of ATP determinations to predict in
vivo red cell viability after in vitro storage. In contract, the correlation between
prestorage ATP levels and poststorage R.B.C. viability was not great enough to be
of predictive value. Of ten other biochemical and hematological measures, only poststorage
osmotic fragility was moderately correlated with poststorage red cell viability.
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Article info
Publication history
Accepted:
January 23,
1967
Received:
October 24,
1966
Footnotes
☆This investigation was supported in part by Research Grants AM-09919 and AM-09381, and by Career Development Award 1-K3-AM-7959 (Dr. Brewer), from the National Institute of Arthritis and Metabolic Diseases, and in part by the R & D Command, Office of the Surgeon General, Department of the Army, under Contract DA-49-193-MD-2855.
Identification
Copyright
© 1967 Published by Elsevier Inc.