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In a study involving 37 subjects, whole blood was stored at 4 °C. for 21 and 28 days in either ACD or CPD anticoagulant, following which, the in vivo viability of the stored red cells was measured. There was a high degree of correlation (R = 0.95) between the postinfusion viability of stored cells and poststorage adenosine triphosphate (ATP) levels. This indicates the potential use of ATP determinations to predict in vivo red cell viability after in vitro storage. In contract, the correlation between prestorage ATP levels and poststorage R.B.C. viability was not great enough to be of predictive value. Of ten other biochemical and hematological measures, only poststorage osmotic fragility was moderately correlated with poststorage red cell viability.
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Accepted: January 23, 1967
Received: October 24, 1966
☆This investigation was supported in part by Research Grants AM-09919 and AM-09381, and by Career Development Award 1-K3-AM-7959 (Dr. Brewer), from the National Institute of Arthritis and Metabolic Diseases, and in part by the R & D Command, Office of the Surgeon General, Department of the Army, under Contract DA-49-193-MD-2855.
© 1967 Published by Elsevier Inc.