Metabolic basis of aminonucleoside nephrosis in rats. II. Inhibition of renal gluconeogenesis by aminonucleoside

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      Inhibition of renal gluconeogenesis from pyruvate, α-oxoglutarate (α-OG), and succinate was demonstrable at 24 hours after a single intravenous injection of aminonucleoside before abnormal proteinuria began. Inhibition of renal gluconeogenesis increased as the nephrotic syndrome developed. Among the substrates tested, inhibition of gluconeogenesis from α-OG was much greater than that from pyruvate, succinate, or fumarate. On the other hand, glucose formation from glycerol was increased in the nephrotic group. Intravenous injection of aminonucleoside decreased the fasting blood glucose level within 4 hours. Decrease of blood glucose level was not due to increased utilization of glucose by muscle.
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