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Urine beta-glucuronidase activity was studied in experimental rat staphylococcal pyelonephritis. Staphylococcus aureus produced a severe acute pyelonephritis and resulted in elevated urine beta-glucuronidase activity consistently during the first week of renal infection and intermittently thereafter (2 to 4 weeks). While pyuria attended increased urine enzyme activity in the first week of renal infection, the increased enzyme activity could not be accounted for by pyuria per se. Urine beta-glucuronidase activity, although no more efficient than pyuria or positive urine culture at death in detecting staphylococcal pyelonephritis, provided an additional means for monitoring the renal injury associated with experimental infection of the kidney.
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Accepted: September 13, 1968
Received: May 22, 1968
☆This work supported in part by Training Grant AM 05069-12 from the National Institute of Arthritis and Metabolic Diseases.
☆☆Work done during the tenure of a United States Public Health Service Traineeship, Training Grant AM 05069-12 from the National Institute of Arthritis and Metabolic Diseases.
© 1969 Published by Elsevier Inc.