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Abstract
Urine beta-glucuronidase activity was studied in experimental rat staphylococcal pyelonephritis.
Staphylococcus aureus produced a severe acute pyelonephritis and resulted in elevated urine beta-glucuronidase
activity consistently during the first week of renal infection and intermittently
thereafter (2 to 4 weeks). While pyuria attended increased urine enzyme activity in
the first week of renal infection, the increased enzyme activity could not be accounted
for by pyuria per se. Urine beta-glucuronidase activity, although no more efficient
than pyuria or positive urine culture at death in detecting staphylococcal pyelonephritis,
provided an additional means for monitoring the renal injury associated with experimental
infection of the kidney.
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References
- Urinary beta-glucuronidase activity in patients with urinary tract infection.New England J. Med. 1965; 272: 70
- Estimation of beta-glucuronidase activity in urinary-tract infection.New England J. Med. 1967; 276: 1468
- Beta-glucuronidase excretion in hypertensive patients.Am. J. M. Sc. 1967; 253: 174
- Urine beta-glucuronidase activity in urinary tract disease.J. Urology. 1967; 97: 352
- Urine beta-glucuronidase in renal injury. I. Enzyme assay conditions and response to mercuric chloride in rats.J. Lab. & Clin. Med. 1969; 73: 6
- Prevention of pyelonephritis by water diuresis: Evidence for the role of medullary hypertonicity in promoting renal infection.J. Clin. Invest. 1965; 44: 73
- Experimental pyleonephritis. IX. The bacteriological course and morphological consequences of staphylococcal pyelonephritis in the rat, with consideration of the specificity of the pathological changes observed.Yale J. Biol. Med. 1961; 34: 40
- Staphylococcal phosphatase, glucuronidase, and sulphatase.J. Path. Bact. 1951; 63: 57
- Hematogenous pyelonephritis in rats. I. Its pathogenesis when produced by a simple new method.J. Clin. Invest. 1955; 34: 1489
- Pyelonephritis. I. Observations on the course of chronic non-obstructed enterococcal infection in the kidney of the rat.Yale J. Biol. Med. 1961; 33: 372
- Rat-kidney lysosomes: Isolation and properties.Biochem. J. 1965; 95: 731
- Staphylococcal leucocidins.Brit. J. Exper. Path. 1957; 38: 123
- The extrusion of protein from rabbit polymorphonuclear leukocyte treated with staphylococcal leucocidin.Biochem. J. 1961; 82: 9
- Application of an improved glucuronidase assay method to the study of human blood beta-glucuronidase.J. Biol. Chem. 1948; 173: 449
- Beta-glucuronidase of human white blood cells.Blood. 1950; 5: 864
- Studies on beta-glucuronidase from E. coli.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 76. 1951: 672
- Intracellular response to an iso-immune reaction at the surface of ascites tumor cells.Nature. 1961; 192: 1302
- Human reactions to staphylococcal antigens.J. Immunol. 1967; 99: 269
Article info
Publication history
Accepted:
September 13,
1968
Received:
May 22,
1968
Footnotes
☆This work supported in part by Training Grant AM 05069-12 from the National Institute of Arthritis and Metabolic Diseases.
☆☆Work done during the tenure of a United States Public Health Service Traineeship, Training Grant AM 05069-12 from the National Institute of Arthritis and Metabolic Diseases.
Identification
Copyright
© 1969 Published by Elsevier Inc.