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Research Article| Volume 73, ISSUE 1, P17-24, January 1969

Urine beta-glucuronidase in renal injury. II. Excretion patterns in experimental staphylococcal pyelonephritis in rats

  • Donald Coonrod
    Affiliations
    From the Samuel J. Sackett Research Laboratories Chicago, Ill., USA

    From Infectious Diseases-Hypersensitivity Section, Department of Medicine, Northwestern University Medical Center Chicago, Ill., USA
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  • Philip Y. Paterson
    Affiliations
    From the Samuel J. Sackett Research Laboratories Chicago, Ill., USA

    From Infectious Diseases-Hypersensitivity Section, Department of Medicine, Northwestern University Medical Center Chicago, Ill., USA
    Search for articles by this author
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      Abstract

      Urine beta-glucuronidase activity was studied in experimental rat staphylococcal pyelonephritis. Staphylococcus aureus produced a severe acute pyelonephritis and resulted in elevated urine beta-glucuronidase activity consistently during the first week of renal infection and intermittently thereafter (2 to 4 weeks). While pyuria attended increased urine enzyme activity in the first week of renal infection, the increased enzyme activity could not be accounted for by pyuria per se. Urine beta-glucuronidase activity, although no more efficient than pyuria or positive urine culture at death in detecting staphylococcal pyelonephritis, provided an additional means for monitoring the renal injury associated with experimental infection of the kidney.
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