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Research Article| Volume 73, ISSUE 1, P54-59, January 1969

Disappearance of adenosine diphosphate in vivo

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      Abstract

      ADP (12 mg. per kilogram in 8 ml.) was injected rapidly into the pulmonary artery of live dogs. This produced marked hypotension in the pulmonary artery persisting for 30 minutes and in the systemic circulation for 5 minutes. No increase in plasma ADP, however, could be found 1 to 2 minutes after injection. Decreased heart rate persisted for 10 minutes, but increased ventilation rate and decreased tidal volume were noted for only 1 minute after ADP injection. Additional quantitative studies demonstrated that ADP passed through the pulmonary circulation in large amounts but could not be detected after 1 minute in vivo. ADP levels decrease rapidly in the intact animal compared to ADP levels in vitro.
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