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Abstract
A previously undescribed binder of vitamin B12 was found in the plasma of 8 patients with polycythemia vera in relapse. It could
be separated from the normal plasma B12 transport proteins, transcobalamin I and II. The polycythemia vera (PV) binder (1)
was not retained on CM-cellulose, (2) had α2- to β-mobility at pH 8.6, (3) was not taken up by HeLa cells, (4) did not carry endogenous
B12, (5) shared antibody reactions with TC I, and (6) had a molecular size of 121,000.
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Article info
Publication history
Accepted:
September 24,
1968
Received:
August 3,
1968
Footnotes
☆This work supported in part by National Institutes of Health Grant AM02808.
Identification
Copyright
© 1969 Published by Elsevier Inc.