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Contact with human skin accelerated the clotting time of human plasma and whole blood. This clot-promoting activity was greatest in those areas rich in sebaceous secretion, was reduced by prior cleansing of the skin with alcohol, and was diminished if the plasma tested was deficient in Hageman factor. These experiments are compatible with the suggestion that the clot-promoting activity of skin requires the presence of Hageman factor and may be related to a component of the surface film, perhaps the fatty acid in sebaceous secretion.
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Accepted: September 24, 1968
Received: August 5, 1968
☆This study was supported in part by Research Grant HE 01661 from the National Heart Institute, the National Institutes of Health, United States Public Health Service, and in part by a grant from the American Heart Association.
© 1969 Published by Elsevier Inc.