This paper is only available as a PDF. To read, Please Download here.
Abstract
Contact with human skin accelerated the clotting time of human plasma and whole blood.
This clot-promoting activity was greatest in those areas rich in sebaceous secretion,
was reduced by prior cleansing of the skin with alcohol, and was diminished if the
plasma tested was deficient in Hageman factor. These experiments are compatible with
the suggestion that the clot-promoting activity of skin requires the presence of Hageman
factor and may be related to a component of the surface film, perhaps the fatty acid
in sebaceous secretion.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Translational ResearchAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Activation of factors XII (Hageman) and XI (PTA) by skin contact.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 122. 1966: 16
- Studies on the action of Hageman factor: Evidence that activated Hageman factor in turn activates plasma thromboplastin antecedent.J. Clin. Invest. 1961; 40: 803
- Studies on the nature of the circulating anticoagulant directed against antihemophilic factor: With notes on an assay for antihemophilic factor.Blood. 1962; 20: 137
- Activation of Hageman factor by saturated fatty acids.Australian J. Exper. Biol. & M. Sc. 1962; 40: 505
- Physiology and biochemistry of the skin.The University of Chicago Press, Chicago1954
- The contact phase of blood coagulation.Blackwell Scientific Publications, Oxford1964
- The acceleration of thrombus formation by certain fatty acids.J. Clin. Invest. 1962; 41: 1199
- On the biogenesis of the free fatty acids in human skin surface fat.J. Invest. Dermatol. 1957; 29: 423
- Studies of sebum. 6. The determination of the component fatty acids of human forearm sebum by gas-liquid chromatography.Biochem. J. 1956; 63: 269
- The clot-promoting effect of soaps of long-chain saturated fatty acids.J. Clin. Invest. 1963; 42: 1569
- Activation of Hageman clotting factor (HF) by long-chain saturated fatty acids (LSFA).in: ed. 2. Fed. Proc. 22. 1963: 163
- The fatty acid patterns of plasma lipids during alimentary lipemia.J. Clin. Invest. 1959; 38: 1544
- The interaction of human serum albumin with long-chain fatty acid anions.J. Am. Chem. Soc. 1958; 80: 3892
- Relationship of whole blood clotting time to physiological variations in circulating saturated free fatty acids.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 119. 1965: 588
- The uses of sebum.in: The sebaceous glands. ed. 2. Advances in biology of skin. vol. IV. The Macmillan Company, New York1963
Article info
Publication history
Accepted:
September 24,
1968
Received:
August 5,
1968
Footnotes
☆This study was supported in part by Research Grant HE 01661 from the National Heart Institute, the National Institutes of Health, United States Public Health Service, and in part by a grant from the American Heart Association.
Identification
Copyright
© 1969 Published by Elsevier Inc.
