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Research Article| Volume 73, ISSUE 1, P91-102, January 1969

Changes in coagulation and fibrinolysis after orthotopic canine liver homotransplantation

  • Liberto Pechet
    Affiliations
    From the Departments of Pathology, Medicine, and Surgery, University of Colorado Medical Center Denver, Colo., USA

    From the Denver Veterans Administration Hospital Denver, Colo., USA
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  • Carl G. Groth
    Footnotes
    Affiliations
    From the Departments of Pathology, Medicine, and Surgery, University of Colorado Medical Center Denver, Colo., USA

    From the Denver Veterans Administration Hospital Denver, Colo., USA
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  • Pierre M. Daloze
    Footnotes
    Affiliations
    From the Departments of Pathology, Medicine, and Surgery, University of Colorado Medical Center Denver, Colo., USA

    From the Denver Veterans Administration Hospital Denver, Colo., USA
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  • Author Footnotes
    ∗ United States Public Health Service International Postdoctoral Research Fellow.
    ∗∗ Fellow of the McLaughin Foundation, Toronto, Ont., Canada.
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      Abstract

      Coagulation and fibrinolysis were studied in 22 dogs subjected to orthotopic liver homotransplantation. In 16 experiments the organs were transplanted promptly. In 6 others, the livers were first preserved in vitro for 24 hours. The following changes took place during the operations: A decrease in clotting factors I, II, VII, VIII, IX, X, a decrease in platelets, and excessive fibrinolysis. These abnormalities were not prevented by EACA and protamine, nor by heparin. The degree and duration of the abnormalities appeared to be related to the functional integrity of the homograft. In dogs receiving damaged livers, the abnormalities were severe and persisted after homograft revascularization; the animals died from uncontrollable bleeding. Recipients of adequately preserved livers showed only moderate and reversible changes, and no excessive bleeding occurred. The abnormalities observed were interpreted as resulting from consumption coagulopathy accompanied by pathologic fibrinolysis.
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