Advertisement
Translational Research
Advanced searchSave search
Research Article| Volume 73, ISSUE 1, P121-128, January 1969

Erythropoietin activity in anephric, allotransplanted, unilaterally nephrectomized, and intact man

  • E.A. Mirand
    Footnotes
    Affiliations
    From Roswell Park Memorial Institute and Departments of Biochemical Pharmacology and Urology, State University of New York at Buffalo, Buffalo, N. Y., USA
    Search for articles by this author
  • G.P. Murphy
    Footnotes
    Affiliations
    From Roswell Park Memorial Institute and Departments of Biochemical Pharmacology and Urology, State University of New York at Buffalo, Buffalo, N. Y., USA
    Search for articles by this author
  • R.A. Steeves
    Footnotes
    Affiliations
    From Roswell Park Memorial Institute and Departments of Biochemical Pharmacology and Urology, State University of New York at Buffalo, Buffalo, N. Y., USA
    Search for articles by this author
  • J.M. Groenewald
    Footnotes
    Affiliations
    From the Departments of Surgery and Urology, the University of Stellenbosch and the Karl Bremer Hospital, Bellville, Cape Province, South Africa
    Search for articles by this author
  • J.N. DeKlerk
    Footnotes
    Affiliations
    From the Departments of Surgery and Urology, the University of Stellenbosch and the Karl Bremer Hospital, Bellville, Cape Province, South Africa
    Search for articles by this author
  • Author Footnotes
    ∗ State University of New York at Buffalo, N. Y.
    ∗∗ University of Stellenbosch and the Karl Bremer Hospital, Bellville, Cape Province, South Africa.
DOI:https://doi.org/10.5555/uri:pii:0022214369900626
Erythropoietin activity in anephric, allotransplanted, unilaterally nephrectomized, and intact man
Previous ArticleThe nature of disaccharidases in human leukocytes
Next ArticleTritium excretion of normotensive and hypertensive subjects after administration of tritiated norepinephrine
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Plasma erythropoietin (ESF) activity was determined in anephric, renal allotransplanted, unilateral nephrectomized, and intact human beings before and after androgen treatment. Increased ESF activity shown in anephric patients before and after androgen treatment provides further evidence that extrarenal site or sites for ESF are present in man. Four out of 7 plasma specimens obtained from anephric patients showed significant ESF activity after androgen injection. These results suggest that the site or sites for extrarenal ESF in the man, like the renal site, are responsive to exogenous testosterone administration. A patient with an allograft kidney also demonstrated a very marked increase in ESF activity in response to androgen treatment and following an episode of bleeding. The androgen-erythropoietin response in male patients with postunilateral nephrectomy for kidney carcinoma was similar to that seen in anephric human beings following androgen treatment.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Mirand E.A.
        • Gordon A.S.
        • Wenig J.
        Mechanism of testosterone action in erythropoiesis.
        Nature. 1965; 206: 270
        • Fried W.
        • Gurney C.W.
        Erythropoietic effect of plasma from mice receiving testosterone.
        Nature. 1965; 206: 1160
        • Mirand E.A.
        • Johnston G.S.
        • Murphy G.P.
        • Gordon A.S.
        Effects of testosterone on renal hemodynamics and erythropoietin release in dogs.
        Invest. Urol. 1966; 4: 203
        • Gordon A.S.
        • Mirand E.A.
        • Wenig J.
        • Katz R.
        • Zanjani E.D.
        Androgen actions on erythropoiesis.
        Ann. New York Acad. Sc. 1968; 149: 318
        • Fried W.
        • Gurney C.W.
        The erythropoietin-stimulating effects of androgens.
        Ann. New York Acad. Sc. 1968; 149: 356
        • Mirand E.A.
        Studies on erythropoietin in tamarins.
        Invest. Urol. 1965; 2: 579
        • Mirand E.A.
        • Murphy G.P.
        • Steeves R.A.
        • Groenewald J.H.
        • van Zyl J.J.W.
        • Retief F.P.
        Erythropoietin release in baboons after renal allotransplantation.
        in: ed. 4. Proc. Soc. Exper. Biol. & Med. 128. 1968: 785
        • Mirand E.A.
        Renal and extrarenal relations to erythropoietin production in animals and man.
        South African M. J. 1968; 42: 462
        • Mirand E.A.
        • Murphy G.P.
        • Steeves R.A.
        • Weber H.W.
        • Retief F.P.
        Extrarenal production of erythropoietin in man.
        Acta haemat. 1968; 39: 359
        • Naets J.P.
        • Wittek M.
        Erythropoiesis, in anephric man.
        Lancet. 1968; 1: 941
        • Mirand E.A.
        • Steeves R.A.
        • Groenewald J.H.
        • van Zyl J.J.W.
        • Murphy G.P.
        Extrarenal erythropoietin production in the baboon.
        in: Proc. Soc. Exper. Biol. & Med. 1968 (In press)
        • Mirand E.A.
        • Prentice T.C.
        Presence of plasma erythropoietin in hypoxic rats with or without kidney(s) and/or spleen.
        in: ed. 4. Proc. Soc. Exper. Biol. & Med. 96. 1957: 49
        • Mirand E.A.
        • Prentice T.C.
        • Slaunwhite W.R.
        Current studies on the role of erythropoietin in erythropoiesis.
        Ann. New York Acad. Sc. 1959; 77: 677
        • Murphy G.P.
        • Mirand E.A.
        • Johnston G.S.
        • Schirmer H.K.A.
        Correlation of renal metabolism with erythropoietin release in hypertensive dogs with renal artery stenosis.
        Invest. Urol. 1967; 4: 372
        • Piliero S.J.
        • Medici P.T.
        • Gordon A.S.
        Production of the circulating erythropoietic factor in hypoxic endocrine-deficient rats.
        in: ed. 4. Proceedings of the VII Congress of the International Society of Hematology. vol. 2. Grune & Stratton, Inc, New York1958: 627 (Part 1)
        • Gallagher M.I.
        • McCarthy J.J.
        • Lange R.D.
        Erythropoietin production in uremic rabbits.
        J. Lab. & Clin. Med. 1961; 57: 281
        • Baciu I.
        • Oprisiu C.
        • Dorofteiu M.
        • Rosenfeld E.
        • Rusiu M.
        • Cherebetiu C.
        Le rein et la production de l'erythropoietine.
        J. Physiol. 1962; 54: 441
        • Hollenberg N.K.
        • Retik A.B.
        • Rosen S.M.
        • Murray J.E.
        • Merrill J.P.
        The role of vasoconstriction in the ischemia of renal allograft rejection.
        Transplantation. 1968; 6: 59
        • Fisher J.W.
        • Hatch F.E.
        • Roh B.L.
        • Allen R.C.
        • Kelly B.J.
        Erythropoietin inhibitor in kidney extracts and plasma from anemic uremic human subjects.
        Blood. 1968; 31: 440
        • Nathan D.G.
        • Schupak E.
        • Stohlman F.J.
        • Merrill J.P.
        Erythropoiesis in anephric man.
        J. Clin. Invest. 1964; 43: 2158
        • Mirand E.A.
        • Murphy G.P.
        • Bennett T.E.
        • Grace Jr., J.T.
        Erythropoietic response to repeated hemorrhage in renal allotransplanted, nephrectomized or intact dogs.
        Life Sc. 1968; 7: 689
        • Mirand E.A.
        • Steeves R.A.
        • Lange R.D.
        • Grace Jr., J.T.
        Virus-induced polycythemia in mice: Erythropoiesis without erythropoietin.
        in: ed. 4. Proc. Soc. Exper. Biol. & Med. 128. 1968: 844

      Article info

      Publication history

      Accepted: October 4, 1968
      Received: July 13, 1968

      Footnotes

      ☆These studies were supported in part by United States Public Health Service Grants CA-08847 and CA-07745, the John A. Hartford Foundation, Inc., the University of Stellenbosch, the Cape Provincial Administration, and the Council for Scientific and Industrial Research.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214369900626

      Copyright

      © 1969 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX