Advertisement
Research Article| Volume 73, ISSUE 1, P129-134, January 1969

Tritium excretion of normotensive and hypertensive subjects after administration of tritiated norepinephrine

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The excretion of a standard test dose of H3NE was greater in patients with essential hypertension than in normal subjects. This abnormality in catecholamine metabolism was not related to renal function but appeared to reflect a defect in internal handling of H3NE by the patient with essential hypertension. The test procedure may be of diagnostic usefulness for the detection of essential hypertension.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Gitlow S.
        • Mendlowitz M.
        • Kruk E.
        • Wilk S.
        • Wolf R.L.
        • Naftchi N.
        Norepinephrine metabolism in essential hypertension.
        J. Clin. Invest. 1963; 42 (Abst.): 934
        • Gitlow S.E.
        • Mendlowitz M.
        • Wilk E.K.
        • Wilk S.
        • Wolf R.L.
        • Naftchi N.E.
        Plasma clearance of D,L-β-H3-norepinephrine in normal human subjects and patients with essential hypertension.
        J. Clin. Invest. 1964; 43: 2009
        • Gitlow S.E.
        • Mendlowitz M.
        • Wilk E.K.
        • Wolf R.L.
        • Wilk S.
        Metabolism of D,L-β-H3-norepinephrine in patients with high blood pressure.
        in: Proc. Council for High Blood Pressure Res. ed. 4. Am. Heart A., Hypertension. 13. 1965: 31
        • Gitlow S.E.
        • Mendlowitz M.
        • Smith A.
        • Gall E.
        • Wolf R.L.
        • Naftchi N.
        Pharmacology and metabolism of norepinephrine in patients with essential hypertension.
        Am. J. Cardiol. 1962; 9: 717
        • Gitlow S.E.
        • Mendlowitz M.
        • Khassis S.
        • Cohen G.
        • Sha J.
        The diagnosis of pheochromocytoma by determination of urinary 3-methoxy, 4-hydroxymandelic acid.
        J. Clin. Invest. 1960; 39: 221
        • Vaquez J.H.
        Hypertension.
        in: ed. 4. Rap. Congr. franç. de méd. 7. 1904: 338
        • Goldenberg M.
        • Pines K.L.
        • Baldwin E.de F
        • Greene D.G.
        • Reh C.E.
        The hemodynamic response of man to norepinephrine and epinephrine and its relation to the problem of hypertension.
        Am. J. Med. 1948; 5: 792
        • Printzmetal M.
        • Wilson C.
        The nature of the peripheral resistance in arterial hypertension with special reference to the vasomotor system.
        J. Clin. Invest. 1936; 15: 63
        • Gitlow S.E.
        • Mendlowitz M.
        • Kruk E.
        • Khassis S.
        Diagnosis of pheochromocytoma by assay of catecholamine metabolites.
        Circulation Res. 1961; 9: 746
        • Sjoerdsma A.
        Relationships between alterations in amine metabolism and blood pressure.
        Circulation Res. 1961; 9: 734
        • Doyle A.E.
        • Fraser J.R.E.
        • Marshall R.J.
        Reactivity of forearm vessels to vasoconstrictor substances in hypertensive and normotensive subjects.
        Clin. Sc. 1959; 18: 441
        • Mendlowitz M.
        • Torosdag S.M.
        • Sharney L.
        Force and work of digital arteriolar smooth muscle contraction in hypertension.
        J. Appl. Physiol. 1957; 10: 436
        • Gitlow S.E.
        • Naftchi N.
        • Mendlowitz M.
        The effect of iproniazid on norepinephrine sensitivity of the digital blood vessels.
        in: Moyer J. Hypertension. W. B. Saunders Company, Philadelphia1959: 409
        • Axelrod J.
        • Weil-Malherbe H.
        • Tomchick R.
        The physiological disposition of H3-epinephrine and its metabolite metanephrine.
        J. Pharmacol. & Exper. Therap. 1959; 127: 251
        • Pickering G.W.
        The vascular physiology of hypertension.
        Advances Int. Med. 1950; 4: 445
        • Wolf R.L.
        • Roboz J.
        • Mendlowitz M.
        Norepinephrine metabolism in hypertension.
        in: ed. 4. Fed. Proc. 27. 1968: 602
        • Kopin I.J.
        Storage and metabolism of catecholamines: The role of monamine oxidase.
        Pharmacol. Rev. 1964; 16: 179
        • Louis W.J.
        • Spector S.
        • Tabei R.
        • Sjoerdsma A.
        Noradrenaline in the heart of the spontaneously hypertensive rat.
        Lancet. 1968; 1: 1013
        • Naftchi N.E.
        • Taylor M.W.
        Metabolism of intravenously infused tritiated norepinephrine (NE) contrasted with that of endogenous NE in various vertebrate species.
        in: ed. 4. Fed. Proc. 27. 1968: 711
        • Krakoff L.R.
        • de Champlain J.
        • Axelrod J.
        Abnormal storage of norepinephrine in essential hypertension in the rat.
        Circulation Res. 1967; 21: 583