This paper is only available as a PDF. To read, Please Download here.
The excretion of a standard test dose of H3NE was greater in patients with essential hypertension than in normal subjects. This abnormality in catecholamine metabolism was not related to renal function but appeared to reflect a defect in internal handling of H3NE by the patient with essential hypertension. The test procedure may be of diagnostic usefulness for the detection of essential hypertension.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Translational Research
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Norepinephrine metabolism in essential hypertension.J. Clin. Invest. 1963; 42 (Abst.): 934
- Plasma clearance of D,L-β-H3-norepinephrine in normal human subjects and patients with essential hypertension.J. Clin. Invest. 1964; 43: 2009
- Metabolism of D,L-β-H3-norepinephrine in patients with high blood pressure.in: Proc. Council for High Blood Pressure Res. ed. 4. Am. Heart A., Hypertension. 13. 1965: 31
- Pharmacology and metabolism of norepinephrine in patients with essential hypertension.Am. J. Cardiol. 1962; 9: 717
- The diagnosis of pheochromocytoma by determination of urinary 3-methoxy, 4-hydroxymandelic acid.J. Clin. Invest. 1960; 39: 221
- Hypertension.in: ed. 4. Rap. Congr. franç. de méd. 7. 1904: 338
- The hemodynamic response of man to norepinephrine and epinephrine and its relation to the problem of hypertension.Am. J. Med. 1948; 5: 792
- The nature of the peripheral resistance in arterial hypertension with special reference to the vasomotor system.J. Clin. Invest. 1936; 15: 63
- Diagnosis of pheochromocytoma by assay of catecholamine metabolites.Circulation Res. 1961; 9: 746
- Relationships between alterations in amine metabolism and blood pressure.Circulation Res. 1961; 9: 734
- Reactivity of forearm vessels to vasoconstrictor substances in hypertensive and normotensive subjects.Clin. Sc. 1959; 18: 441
- Force and work of digital arteriolar smooth muscle contraction in hypertension.J. Appl. Physiol. 1957; 10: 436
- The effect of iproniazid on norepinephrine sensitivity of the digital blood vessels.in: Moyer J. Hypertension. W. B. Saunders Company, Philadelphia1959: 409
- The physiological disposition of H3-epinephrine and its metabolite metanephrine.J. Pharmacol. & Exper. Therap. 1959; 127: 251
- The vascular physiology of hypertension.Advances Int. Med. 1950; 4: 445
- Norepinephrine metabolism in hypertension.in: ed. 4. Fed. Proc. 27. 1968: 602
- Storage and metabolism of catecholamines: The role of monamine oxidase.Pharmacol. Rev. 1964; 16: 179
- Noradrenaline in the heart of the spontaneously hypertensive rat.Lancet. 1968; 1: 1013
- Metabolism of intravenously infused tritiated norepinephrine (NE) contrasted with that of endogenous NE in various vertebrate species.in: ed. 4. Fed. Proc. 27. 1968: 711
- Abnormal storage of norepinephrine in essential hypertension in the rat.Circulation Res. 1967; 21: 583
Accepted: October 5, 1968
Received: July 26, 1968
☆Supported by National Heart Institute Grant No. HE 06546.
© 1969 Published by Elsevier Inc.