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Research Article| Volume 73, ISSUE 1, P144-153, January 1969

Reduction in plasma factor XIII (fibrin stabilizing factor) concentration during pregnancy

DOI:https://doi.org/10.5555/uri:pii:0022214369900651
Reduction in plasma factor XIII (fibrin stabilizing factor) concentration during pregnancy
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      Abstract

      A method for assay of plasma coagulation factor XIII (fibrin stabilizing factor) is described using assay clots incorporating 125I-labeled fibrin. After exposure to solvent, the assay end point is quantified by determinations of supernatant radioactivity. Objective determinations of assay end point yields excellent methodological reproducibility. Normal men and women showed similar plasma factor XIII concentrations, and long-term administration of birth control medication did not influence factor XIII concentrations in the female. In contrast, plasma factor XIII concentration diminished steadily during pregnancy reaching a level approximately 50 per cent of normal at term (p < 0.001). The regression between diminution in factor XIII concentrations and duration of pregnancy was highly significant (r = 0.79, p < 0.001).
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      References

        • Alexander B.
        • Meyers L.
        • Kenny J.
        • Goldstein R.
        • Gurewich V.
        • Gainspoon L.
        Blood coagulation in pregnancy.
        New England J. Med. 1954; 254: 358
        • Ratnoff O.D.
        • Holland T.R.
        Coagulation components in normal and abnormal pregnancies.
        Ann. New York Acad. Sc. 1958; 75: 626
        • Kasper C.K.
        • Hoag M.S.
        • Aggeler P.M.
        • Stone S.
        Blood clotting factors in pregnancy: factor VIII concentrations in normal and AHF-deficient women.
        Obst. & Gynec. 1964; 24: 242
        • Talbert L.M.
        • Langdell R.D.
        Normal values of certain factors in the blood clotting mechanism in pregnancy.
        Am. J. Obst. & Gynec. 1964; 90: 44
        • Todd M.E.
        • Thompson J.H.
        • Bowie E.J.W.
        • Owen C.A.
        Changes in blood coagulation during pregnancy.
        in: ed. 4. Mayo Clin. Proc. 40. 1965: 370
        • Loewy A.G.
        Enzymatic control of insoluble fibrin formation.
        in: Laki K. Fibrinogen. Marcel Dekker, Inc, New York1968
        • Sigg P.
        The monoiodoacetate (MIA) tolerance test, a new quantitative method for the fibrin stabilizing factor (factor XIII) assay.
        Thromb. et Diath. Haemorrh. 1966; 15: 238
        • Swigert S.
        • Koppel J.L.
        • Olwin J.H.
        Selective inactivation of fibrin stabilizing factor contaminant in fibrinogen.
        Nature. 1963; 198: 797
        • Urayama T.
        • Lorand L.
        A fluorescent rate assay for the fibrin stabilizing factor, F.S.F.
        in: ed. 4. Fed. Proc. 27. 1968: 693 (Abst.)
        • Gormsen J.
        • Fletcher A.P.
        • Alkjaersig N.
        • Sherry S.
        Enzymic lysis of plasma clots: The influence of fibrin stabilization on lysis rates.
        Arch. Biochem. 1967; 120: 654
        • Fletcher A.P.
        The thrombolytic activity of plasma (isotopic method).
        in: Tocantins L.M. Kazal L.A. Blood coagulation hemorrhage and thrombosis. Grune & Stratton, Inc, New York1964
        • Alami S.G.
        • Hampton J.W.
        • Race G.J.
        • Speer R.
        The relationship of plasma fibrinogen (factor I) level to fibrin stabilizing factor (factor XIII) activity.
        Blood. 1968; 31: 93
        • Mosesson M.W.
        • Finlayson J.S.
        Subfractions of human fibrinogen; preparation and analysis.
        J. Lab. & Clin. Med. 1963; 62: 663
        • Pritchard J.A.
        Plasma cholinesterase activity in normal pregnancy and in eclamptogenic toxemias.
        Am. J. Obst. & Gynec. 1955; 70: 1083
        • Shnider S.M.
        Serum cholinesterase activity during pregnancy, labor, and the puerperium.
        Anesthesiology. 1965; 26: 335
        • Ratnoff O.D.
        • Colopy J.E.
        • Pritchard J.A.
        The blood-clotting mechanism during normal parturition.
        J. Lab. & Clin. Med. 1954; 44: 408
        • Brakman P.
        The fibrinolytic system in human blood during pregnancy.
        Am. J. Obst. & Gynec. 1966; 94: 14
        • Pritchard J.A.
        Changes in blood volume during pregnancy and delivery.
        Anesthesiology. 1965; 26: 393
        • Nussbaum M.
        • Morse B.S.
        Plasma fibrin stabilizing factor activity in various diseases.
        Blood. 1964; 23: 669
        • Alami S.G.
        • Hampton J.W.
        • Race G.J.
        • Speer R.J.
        Fibrin stabilizing factor (factor XIII).
        Am. J. Med. 1968; 44: 1
        • Duckert F.
        • Jung E.
        • Shmerling D.H.
        A hitherto undescribed congenital hemorrhagic diathesis probably due to fibrin stabilizing factor deficiency.
        Thromb. et Diath. Haemorrh. 1960; 5: 179
        • Beck E.
        • Duckert F.
        • Ernst M.
        The influence of fibrin stabilizing factor on the growth of fibroblasts in vitro and wound healing.
        Thromb. et Diath. Haemorrh. 1961; 6: 485
        • Losowsky M.S.
        • Hall R.
        • Goldie W.
        Congenital deficiency of fibrin stabilizing factor, a report of three unrelated cases.
        Lancet. 1965; 2: 156
        • Fisher S.
        • Rikover M.
        • Noar S.
        Factor XIII deficiency with severe hemorrhagic diathesis.
        Blood. 1966; 28: 34

      Article info

      Publication history

      Accepted: October 7, 1968
      Received: August 30, 1968

      Footnotes

      ☆This work was supported by Grants HE-03745 and TI-HE-05814 from the National Heart Institute, and Grant TIAM-5312 from the National Institute of Arthritis and Metabolic Disease, Bethesda, Md.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214369900651

      Copyright

      © 1969 Published by Elsevier Inc.

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