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Abstract
The ouabain-sensitive (OS) and ouabain-insensitive (OI) K uptake and K content of
red blood cells (RBC) were measured in 23 normal subjects, in 10 patients with myocardial
infarction (MI) in the acute stage and after subsidence of acute symptoms, and in
13 patients with acute noncardiac diseases. Total and OS K uptake were lower (p <
0.05 and p < 0.001) in patients during the acute stage of MI (1.68 and 0.99 mEq. per
kilogram of wet weight per hour) than in normal subjects (1.95 and 1.44 mEq. per kilogram
of wet weight per hour) and increased in all MI patients after subsidence of acute
symptoms (1.98 and 1.49 mEq. per kilogram of wet weight per hour, p < 0.02 and p <
0.0025). The abnormality was unrelated to drugs or associated diseases. Low values
of OS K uptake were also found in 5 patients with acute noncardiac diseases. Two of
these patients had acute hepatitis, one had status asthmaticus, and two were in the
early postoperative stage. RBC K content was not significantly different in the 3
groups. Changes in K content paralleled changes in OS K uptake in only half of the
patients with MI. The K transport defect is not specific for acute MI, and more than
one mechanism may be involved.
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Article info
Publication history
Accepted:
June 10,
1970
Received:
February 9,
1970
Footnotes
☆This study was supported by United States Public Health Service Grant No. HE 11244 and Contract 43-68-1333.
Identification
Copyright
© 1970 Published by Elsevier Inc.
