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Abstract
The hepatocytes of the rabbit remove plasma heme as the heme-hemopexin complex. This
was shown by intravenously injecting tracer amounts of radioactively labeled heme
or hemopexin and analyzing tissue slides by radioautography 15, 60, or 120 minutes
thereafter. Heme, labeled with 3H or 59Fe, was injected as heme,
†Heme = ferriprotoporphyrin IX.
heme-hemopexin, heme-albumin, or cyanmethemoglobin. Rabbit hemopexin, labeled with
125I, was given as the heme-hemopexin complex. Regardless of which form of heme was administered
and whether heme or hemopexin was labeled, all radioactive material was found exclusively
in the parenchymal cells of the liver; spleen, kidney, lung, and bone marrow cells
remained free of radioactivity.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
June 17,
1970
Received:
March 9,
1970
Footnotes
☆This work was supported by research grants from the National Heart Institute (HE 08660-07), the Institute of Child Health and Human Development (HD 04445-01), the National Institute of Allergy and Infectious Diseases (A1-07007), and the San Diego County Heart Association (No. 83).
Identification
Copyright
© 1970 Published by Elsevier Inc.