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Abstract
Fourteen patients with Wilson's disease, 10 of their parents and siblings, and 12
control subjects had muscle copper, zinc, and manganese concentrations determined
by the use of neutron-activation analysis. Zinc and manganese concentrations did not
differ significantly in the 3 groups. Although patients with Wilson's disease had
a significant (p < 0.05) increase in mean muscle copper concentration when compared
with that of control subjects, there was too much overlap for this to be a useful
diagnostic test. Ten of the 14 patients with Wilson's disease were estimated to have
an increased amount of copper in their muscle tissues, averaging 4.5 mg. This amount
of copper is small when compared with the excess copper in the liver and central nervous
system of patients with Wilson's disease and suggests that the muscle is only a secondary
site for deposition of copper.
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References
- Tissue copper levels in Chinese patients with Wilson's disease.Neurology. 1963; 13: 155
- Neutron activation analysis for copper in biological material applied to Wilson's disease.J. Clin. Path. 1968; 21: 8
- Prevention of Wilson's disease in asymptomatic patients.New Eng. J. Med. 1968; 278: 352
- Liver-copper levels in liver disease. Studies using neutron activation analysis.Lancet. 1968; 2: 1310
- Histochemical localization of copper with rubeanic acid.Lab. Invest. 1956; 5: 299
- Radioactivation analysis of trace elements in rice plant: Determinations of manganese, magnesium, sodium, potassium, chlorine, bromine, copper, and zinc.Radioisotopes. 1967; 16: 526
- The determination of manganese in urine by neutron activation analysis.Int. J. Appl. Radiat. 1965; 16: 365
- Trace elements in human tissue. II. Adult subjects from the United States.Health Phys. 1963; 9: 103
- Changes in structural components of human body from 6 lunar months to maturity.in: Proc. Soc. Exp. Biol. Med. 43. 1940: 545
- Studies with radioactive copper (64Cu and 67Cu) in relation to the natural history of Wilson's disease.Lancet. 1967; 1: 346
Article info
Publication history
Accepted:
June 26,
1970
Received:
February 16,
1970
Footnotes
☆This work was supported by the Bureau of Medicine and Surgery, Work Units MR005.09-0040A and T.002.
☆☆The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting views of the Navy Department or the Naval Service at large.
Identification
Copyright
© 1970 Published by Elsevier Inc.
