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Abstract
The presence of an inhibitor of hemoglobin synthesis has been detected in rat plasma
and serum. The inhibitor decreased the uptake of 59Fe and incorporation of glycine-2-14C into rat reticulocytes harvested from phenylhydrazine-treated rats. The inhibition
was dose related above plasma volumes of 0.5 ml., the inhibitor activity being threefold
greater in serum from animals with phenylhydrazine-induced anemia than that in normal
serum. The factor was nondialyzable, was precipitated with concentrations of ammonium
sulfate above 40 per cent, and was extractable into butanone-2. The inhibition was
shown not to be due to heme.
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Article info
Publication history
Accepted:
July 8,
1970
Received:
April 21,
1970
Footnotes
☆This investigation was supported by Contract PH43-65-6, General Laboratories and Clinics, National Cancer Institute, United States Public Health Service.
Identification
Copyright
© 1970 Published by Elsevier Inc.
