This paper is only available as a PDF. To read, Please Download here.
Blood flow in various involved skin areas and in forearm subcutaneous tissue in patients with scleroderma was measured by the disappearance rate of a radioisotope from a local depot. Although the averages for cutaneous blood flow in the foreheads and fingertips of patients were significantly decreased compared to those in normal subjects, normal disappearance rates were sometimes obtained from obviously involved sclerodermatous skin in these areas. Forehead blood vessels in patients with scleroderma did not show an increased response to reflex sympathetic nerve stimulation compared to normal subjects. Forearm skin and subcutaneous tissue were clinically involved in all but one patient; however, there was no significant difference in skin or subcutaneous blood flow between patients and normal subjects. Therefore, it seems that sclerodermatous skin does not necessarily have a decreased blood flow and that a decrease in nutritional capillary blood flow is not a primary fault in the disease.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Translational Research
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Hydroxyproline and collagen metabolism. Clinical implications.Ann. Intern. Med. 1965; 63: 672
- Collagen profile in various clinical conditions.Lancet. 1966; 2: 707
- Effect of intravenous epinephrine on skeletal muscle, skin and subcutaneous blood flow.Amer. J. Physiol. 1969; 216: 156
- Forehead blood flow measured by radioisotope disappearance rates.Amer. J. Physiol. 1969; 217: 1134
- The pathophysiology of peripheral blood vessels in collagen diseases.in: Orbison J.L. Smith D.E. The peripheral blood vessels. The Williams & Wilkins Company, Baltimore1963
- Measurement of regional circulation by the local clearance of radioactive sodium.Amer. Heart J. 1949; 28: 321
- Statistical methods. Iowa State College Press, Ames, Iowa1956 ed. 5.
- Evidence for two vascular pathways in skeletal muscle.Clin. Sci. 1961; 20: 367
- Digital arteriography in occlusive arterial disease and clubbing of the fingers.Circulation. 1967; 35: 682
- Some features in angiographic findings in rheumatoid arthritis and scleroderma.Acta Rheum. Scand. 1964; 10: 189
- Scleroderma and pseudoscleroderma.Department of Commerce, Springfield, Va1965
- Physiologic studies in systemic sclerosis (scleroderma).Arch. Intern. Med. 1969; 123: 22
Accepted: July 13, 1970
Received: April 9, 1970
© 1970 Published by Elsevier Inc.