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Abstract
Blood flow in various involved skin areas and in forearm subcutaneous tissue in patients
with scleroderma was measured by the disappearance rate of a radioisotope from a local
depot. Although the averages for cutaneous blood flow in the foreheads and fingertips
of patients were significantly decreased compared to those in normal subjects, normal
disappearance rates were sometimes obtained from obviously involved sclerodermatous
skin in these areas. Forehead blood vessels in patients with scleroderma did not show
an increased response to reflex sympathetic nerve stimulation compared to normal subjects.
Forearm skin and subcutaneous tissue were clinically involved in all but one patient;
however, there was no significant difference in skin or subcutaneous blood flow between
patients and normal subjects. Therefore, it seems that sclerodermatous skin does not
necessarily have a decreased blood flow and that a decrease in nutritional capillary
blood flow is not a primary fault in the disease.
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References
- Hydroxyproline and collagen metabolism. Clinical implications.Ann. Intern. Med. 1965; 63: 672
- Collagen profile in various clinical conditions.Lancet. 1966; 2: 707
- Effect of intravenous epinephrine on skeletal muscle, skin and subcutaneous blood flow.Amer. J. Physiol. 1969; 216: 156
- Forehead blood flow measured by radioisotope disappearance rates.Amer. J. Physiol. 1969; 217: 1134
- The pathophysiology of peripheral blood vessels in collagen diseases.in: Orbison J.L. Smith D.E. The peripheral blood vessels. The Williams & Wilkins Company, Baltimore1963
- Measurement of regional circulation by the local clearance of radioactive sodium.Amer. Heart J. 1949; 28: 321
- ed. 5. Statistical methods. Iowa State College Press, Ames, Iowa1956
- Evidence for two vascular pathways in skeletal muscle.Clin. Sci. 1961; 20: 367
- Digital arteriography in occlusive arterial disease and clubbing of the fingers.Circulation. 1967; 35: 682
- Some features in angiographic findings in rheumatoid arthritis and scleroderma.Acta Rheum. Scand. 1964; 10: 189
- Scleroderma and pseudoscleroderma.Department of Commerce, Springfield, Va1965
- Physiologic studies in systemic sclerosis (scleroderma).Arch. Intern. Med. 1969; 123: 22
Article info
Publication history
Accepted:
July 13,
1970
Received:
April 9,
1970
Identification
Copyright
© 1970 Published by Elsevier Inc.
