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Abstract
The response of dogs to a purified preparation of Ascaris antigen was studied. All
dogs had cutaneous reactions to the Ascaris antigen. This reactivity was not produced
by experimental immunization and was assumed to result from prior parasitic infestation.
No animals with negative skin tests to Ascaris antigen were observed. Skin reactivity
varied in the different animals from undiluted to 10−6 dilutions of the standard Ascaris antigen. Reactions to low dilutions may be irritant
reactions or may be antibody mediated. Reactions to high dilutions of the antigen
are considered to be antibody mediated because they are transferable to the skin of
animals that react only to lower concentrations of the Ascaris antigen. A high percentage
of dogs were sensitive enough to have respiratory responses to the aerosolized antigen
or anaphylaxis when the antigen was given intravenously. The anti-Ascaris antibody
which passively sensitized canine skin was heat labile and was nonprecipitating.
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Patterson, R.: Unpublished data.
Miyamoto, T.: Personal communication.
Article info
Publication history
Accepted:
May 13,
1970
Received:
February 3,
1970
Footnotes
☆This work was supported by the Ernest S. Bazley Grant and by National Institutes of Health Training Grant No. 5 T01-AI-00057 from the National Institute of Allergy and Infectious Diseases.
Identification
Copyright
© 1970 Published by Elsevier Inc.
