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The response of dogs to a purified preparation of Ascaris antigen was studied. All dogs had cutaneous reactions to the Ascaris antigen. This reactivity was not produced by experimental immunization and was assumed to result from prior parasitic infestation. No animals with negative skin tests to Ascaris antigen were observed. Skin reactivity varied in the different animals from undiluted to 10−6 dilutions of the standard Ascaris antigen. Reactions to low dilutions may be irritant reactions or may be antibody mediated. Reactions to high dilutions of the antigen are considered to be antibody mediated because they are transferable to the skin of animals that react only to lower concentrations of the Ascaris antigen. A high percentage of dogs were sensitive enough to have respiratory responses to the aerosolized antigen or anaphylaxis when the antigen was given intravenously. The anti-Ascaris antibody which passively sensitized canine skin was heat labile and was nonprecipitating.
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Patterson, R.: Unpublished data.
Miyamoto, T.: Personal communication.
Accepted: May 13, 1970
Received: February 3, 1970
☆This work was supported by the Ernest S. Bazley Grant and by National Institutes of Health Training Grant No. 5 T01-AI-00057 from the National Institute of Allergy and Infectious Diseases.
© 1970 Published by Elsevier Inc.