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Abstract
Inpatients with amyotrophic lateral sclerosis (ALS) and with other various neuromascular
(NM) diseases were compared in their responses to the intravenous glucose tolerance
test (GTT), the insulin tolerance test (ITT), and the tolbutamide tolerance test:
(TTT). Patients with neuromuscular diseases other than ALS (NM control group) responded
for all studies within the normal range. Higher fasting serum lipid levels but no
significant differences in fasting serum glucose, insulin, or human growth hormone
(HGH) were noted in the ALS group. Lower rates of glucose utilization and higher post-glucose
insulin levels during the intravenous GTT were observed in the ALS group. These and
similar results from the TTT were interpreted as resistance to endogenous insulin
in ALS. The ITT studies showed a similar resistance to exogenous insulin among the
ALS patients. There was no relationships among the metabolic abnormalities and clinical
state of the ALS patients. These data show that ALS patients have insulin resistance
and decreased glucose utilization which cannot be explained purely by muscular dysfunction,
other adventitious factors secondary to this motor neuron disease, or pancreatic dysfunction.
These metabolic abnormalities associated with ALS are differentiated from those of
late-onset diabetes, obesity, inanition, and myotonic dystrophy but not from those
of severe depression.
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Article info
Publication history
Accepted:
May 18,
1970
Received:
February 23,
1970
Footnotes
☆Supported in part by United States Public Health Service Grants MH-13917 and FR-82 to The Clinical Research Center, Shands Teaching Hospital, Gainesville.
Identification
Copyright
© 1970 Published by Elsevier Inc.
