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Abstract
The effects of 2 weeks of absolute bed rest on arteriovenous glucose difference, forearm
blood flow, and peripheral glucose uptake were studied in 9 subjects. A 180 minute
infusion of a 20 per cent glucose solution was administered during a control period
of normal activity, on the fourteenth day of absolute bed rest and on the seventh,
or fourteenth day of post-bed-rest recovery. Venous glucose was recorded continuously
by an AutoAnalyzer. Arterial glucose, serum immunoreactive insulin (IRI), and forearm
blood flow were measured. Glucose loads were varied during the bed-rest and recovery
infusions to match the venous glucose concentrations obtained during the control period
for each subject and thus achieve similar insulinogenic stimuli between periods. While
there were no significant differences in fasting preinfusion arteriovenous glucose
differences or preinfusion peripheral glucose uptakes, there were significant decreases
in peripheral glucose uptake during the bed-rest and the 7 day-recovery glucose infusions
as compared to the control and the 14 day-recovery infusions. There was a significant
decrease in the mean glucose load needed to produce a comparable venous glucose curve
during the bed rest as compared to the control infusion. Mean serum immunoreactive
insulin concentrations were comparable during each of the 3 infusions. The glucose
intolerance of bed rest is due, in part, to an impairment of peripheral glucose uptake
which is not the result of insulin deficiency or insulin antagonists but appears to
be a cellular alteration.
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Article info
Publication history
Accepted:
May 25,
1970
Received:
March 23,
1970
Footnotes
☆Presented in part at the American Physiological Society, Davis, Calif. August 1969.
Identification
Copyright
© 1970 Published by Elsevier Inc.
