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Abstract
Studies were performed to investigate the effect of furosemide, ethacrynic acid, chlormerodrin,
mercaptomerin, chlorothiazide, and acetazolamide on the urinary excretion of calcium,
magnesium, and phosphate. To avoid the effects of extracellular fluid volume contraction
and parathormone stimulation, thyroparathyroidectomized dogs, whose urinary losses
were continuously replaced, were utilized. The administration of all diuretic agents
resulted in a progressive increase in the fractional clearance of calcium, magnesium,
and phosphate as the clearance of sodium increased. Phosphate reabsorptiou occurs
mainly in the proximal tubule; therefore, the increase in phosphate clearance induced
by all the diuretics studied suggests that each of these agents exerts some effect
on the proximal tubule. The rise in fractional clearance of phosphate induced by acetazolamide
and chlorothiazide was greater than that of the other diuretics; however, the rise
in calcium and magnesium produced by these two agents was the smallest. This may be
attributed to the reabsorption of sodium, calcium, and magnesium in the loop of Henle
where acetazolamide and chlorothiazide have little or no effect.
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References
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Article info
Publication history
Accepted:
May 25,
1970
Received:
March 6,
1970
Footnotes
☆This work was supported in part by Grants Nos. HE 5435 and HE 12209 from the National Institutes of Health and by Section Grant 101.124 (Project No. 6-69) from the Veterans Administration Hospital.
Identification
Copyright
© 1970 Published by Elsevier Inc.
