Research Article| Volume 76, ISSUE 2, P293-303, August 1970

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The effect of live attenuated Venezuelan equine encephalomyelitis virus vaccine on serum iron, zinc, and copper concentrations in man

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      Serum iron and zinc concentrations fell early after exposure of volunteers to live attenuated Venezuelan equine encephalomyelitis virus vaccine, with a rise in serum copper concentrations. Alterations in these serum metal concentrations were significantly different from changes expected on the basis of day-to-day variability differences among individuals. The prospective nature of this study and the rapid development of altered serum metal metabolism, even in exposed subjects who remained asymptomatic, suggest that the changes in these metals in the prodromal period represent an early host response to the presence of invading microorganisms. In those subjects who developed febrile illness, the responses became exaggerated and appeared to be related in timing and magnitude to the onset and severity of the febrile reaction. These changes may have significance in providing new approaches to diagnosis and to an improved understanding of host metabolic responses during infectious illness.
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