Research Article| Volume 76, ISSUE 2, P304-310, August 1970

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In vivo synthesis of IgG by rheumatoid synovium

  • Anthony J. Sliwinski
    Reprint requests: Dr. Anthony J. Sliwinski, M.D., Dept. of Medicine, Division of Rheumatic Diseases, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, D. C. 20007.
    From the Division of Rheumatic Diseases, Georgetown University Medical Center Washington, D. C., USA
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  • Nathan J. Zvaifler
    From the Division of Rheumatic Diseases, Georgetown University Medical Center Washington, D. C., USA
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      A study was designed to measure the IgG in synovial fluid which is synthesized by the intact rheumatoid synovium and to estimate the amount produced daily in a knee joint. Radiolabeled albumin I131 and autologous IgG I125 were given to 5 subjects with rheumatoid arthritis, 2 with degenerative arthritis, and 2 with Reiter's syndrome. Serial specific activities were determined on simultaneously obtained synovial fluid and plasma samples. The specific activity of synovial fluid albumin was equal to plasma in all 9 subjects. The specific activity of synovial fluid IgG was identical to plasma IgG in the subjects with degenerative arthritis and Reiter's syndrome, indicating no production of IgG by their synovium. In 5 rheumatoid subjects, the synovial fluid IgG specific activity was consistently less than that of plasma. Twelve to 26 per cent of their IgG was produced locally. Five to 95 mg. of IgG was produced by the synovium of a single knee joint daily.
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        • Pekin T.J.
        • Zvaifler N.J.
        Hemolytic complement in synovial fluid.
        J. Clin. Invest. 1964; 43: 1372
        • Rawson A.
        • Abelson N.M.
        • Hollander J.L.
        Intracytoplasmic particulate complexes in rheumatoid synovial fluids.
        Ann. Intern. Med. 1965; 62: 281
        • Wilkinson M.
        • Jones B.S.
        Serum and synovial fluid proteins in arthritis.
        Ann. Rheum. Dis. 1962; 21: 51
        • Mellors R.C.
        • Heimer R.
        • Corcos J.
        • Korngold L.
        Cellular origin of rheumatoid factor.
        J. Exp. Med. 1959; 110: 875
        • Herman J.H.
        • Bradley J.
        • Smiley J.D.
        Capacity of the rheumatoid synovial membrane to respond to systemic immunization.
        Arthritis Rheum. 1968; 11: 825
        • Ropes M.
        • Bennett G.A.
        • Cobbs S.
        • Jacox R.
        • Jessar R.
        Diagnostic criteria for rheumatoid arthritis.
        Bull. Rheum. Dis. 1958; 9: 175
        • Sliwinski A.J.
        • Zvaifler N.J.
        The removal of aggregated and nonaggregated gamma globulin from rheumatoid joints.
        Arthritis Rheum. 1969; 12: 504
        • Seigel S.
        Nonparametric statistics for the behavioral sciences.
        in: McGraw-Hill Book Company, Inc, New York1956: 116
        • Frick E.
        • Scheid-Seydel L.
        Untersuchungen mit I131-markiertem γ-globulin zur frage der abstammung der liquoreiweisskorper.
        Klin. Wschr. 1958; 36: 857
        • Rodnan G.P.
        • Eisenbeis C.
        • Creighton A.S.
        The occurrence of rheumatoid factor in synovial fluid.
        Amer. J. Med. 1963; 35: 182
        • Claman H.
        • Merrill D.
        Serum immunoglobulins in rheumatoid arthritis.
        J. Lab. Clin. Med. 1966; 67: 850