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Abstract
A study was designed to measure the IgG in synovial fluid which is synthesized by
the intact rheumatoid synovium and to estimate the amount produced daily in a knee
joint. Radiolabeled albumin I131 and autologous IgG I125 were given to 5 subjects with rheumatoid arthritis, 2 with degenerative arthritis,
and 2 with Reiter's syndrome. Serial specific activities were determined on simultaneously
obtained synovial fluid and plasma samples. The specific activity of synovial fluid
albumin was equal to plasma in all 9 subjects. The specific activity of synovial fluid
IgG was identical to plasma IgG in the subjects with degenerative arthritis and Reiter's
syndrome, indicating no production of IgG by their synovium. In 5 rheumatoid subjects,
the synovial fluid IgG specific activity was consistently less than that of plasma.
Twelve to 26 per cent of their IgG was produced locally. Five to 95 mg. of IgG was
produced by the synovium of a single knee joint daily.
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References
- Hemolytic complement in synovial fluid.J. Clin. Invest. 1964; 43: 1372
- Intracytoplasmic particulate complexes in rheumatoid synovial fluids.Ann. Intern. Med. 1965; 62: 281
- Serum and synovial fluid proteins in arthritis.Ann. Rheum. Dis. 1962; 21: 51
- Cellular origin of rheumatoid factor.J. Exp. Med. 1959; 110: 875
- Capacity of the rheumatoid synovial membrane to respond to systemic immunization.Arthritis Rheum. 1968; 11: 825
- Diagnostic criteria for rheumatoid arthritis.Bull. Rheum. Dis. 1958; 9: 175
- The removal of aggregated and nonaggregated gamma globulin from rheumatoid joints.Arthritis Rheum. 1969; 12: 504
- Nonparametric statistics for the behavioral sciences.in: McGraw-Hill Book Company, Inc, New York1956: 116
- Untersuchungen mit I131-markiertem γ-globulin zur frage der abstammung der liquoreiweisskorper.Klin. Wschr. 1958; 36: 857
- The occurrence of rheumatoid factor in synovial fluid.Amer. J. Med. 1963; 35: 182
- Serum immunoglobulins in rheumatoid arthritis.J. Lab. Clin. Med. 1966; 67: 850
Article info
Publication history
Accepted:
May 27,
1970
Received:
April 10,
1970
Footnotes
☆A portion of this work was conducted through the Georgetown University Clinical Study Unit, which is supported by funds from the United States Public Health Service (FR-60); additional support came from Grants AM 5140, AM 12059, and AM 5042.
☆☆Presented in part at the National Meeting of the American Rheumatism Association, Boston, Mass., June 20, 1969.
Identification
Copyright
© 1970 Published by Elsevier Inc.
