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Abstract
Red cell glucose utilization was investigated in term, premature, and intrauterine-growth
retarded infants, and the results were compared to red cell glucose utilization by
separate populations of mixed-age young and old red cells from adults. With the use
of adult young red cells as a control, no statistically significant difference in
neonatal red cell glucose utilization could be found except in premature infants of
less than 35 weeks' gestational age where it was increased. Young adult red cells
consumed more glucose than either a mixed-age red cell population or old adult red
cells. Investigation of the glucose carrier system across the red cell membrane in
the term newborn human infant was shown to be adequate. Both young and old adult red
cells produced approximately 2.0 μM of lactate per micromole of glucose consumed,
but neonatal red cells did not produce lactate with any predictable stoichiometry.
This suggests an alteration in the neonatal red cell to carry anaerobic glycolysis
all the way to lactate. It was also shown that it is erroneous to use whole-blood
glucose as a measure of red cell glucose content. This error can be avoided by using
plasma-water glucose content as there is a direct relation with red cell water-glucose.
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Article info
Publication history
Accepted:
May 31,
1970
Received:
September 3,
1969
Footnotes
☆Supported by United States Public Health Service Grant H5430.
Identification
Copyright
© 1970 Published by Elsevier Inc.
