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Abstract
A fluorometric method for the concurrent determination of DDS, MADDS, and DADDS in
biological fluids has been described. Various tests have been applied that testify
to the validity of the method. Lower limits of variability were 0.004 μg, 0.002 μg,
and 0.2 μg of DDS, MADDS, and DADDS, respectively. The practical limits of sensitivity
were 0.01 μg of DDS and MADDS with the use of 1 ml. of original sample. High sensitivity
for measurement of DADDS was not pursued since no evidence was obtained that this
compound was a metabolite of DDS or MADDS in animals or man. The specificity of the
method has been demonstrated by examination of the contribution of various sulfone
derivatives known, or suspected, to be metabolites of DDS in biological systems. Procedures
for measuring various conjugates of DDS in urine have been described.
Abbreviations:
DDS (4,4′-diaminodiphenyl sulfone), MADDS (4-amino-4′-acetamidodiphenyl sulfone), DADDS (4,4′-diacetamidodiphenyl sulfone), DDS-G (4-amino-4′-N-glucosiduronodiphenyl sulfone), DDS-S (4-amino-4′-sulfamatodiphenyl sulfone), DDS-diS (4,4′-disulfamatodiphenyl sulfone), MADDS-S (4-acetamino-4′-sulfamatodiphenyl sulfone), DDS-H (4-amino-4′-hydroxyaminodiphenyl sulfone), MADDS-H (4-acetamido-4′-hydroxyaminodiphenyl sulfone), DDS-diH (4,4′-dihydroxyaminodiphenyl sulfone), DDS-3-OH (3-hydroxy-4,4′-diaminodiphenyl sulfone), MADDS-3′-OH (3-hydroxy-4-amino-4′-acetamidodiphenyl sulfone), DDS-2-OH (2-hydroxy-4,4′-diaminodiphenyl sulfone), MADDS-2′-OH (2-hydroxy-4-amino-4′-acetamidodiphenyl sulfone), DDS-2,2′-diOH (2,2′-dihydroxy-4,4′-diaminodiphenyl sulfone)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
May 18,
1970
Received:
February 16,
1970
Footnotes
☆Supported in part by the United States-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases (Grant AI-08214) and by Grant RR 05522-07 from the National Institutes of Health, Department of Health, Education and Welfare.
Identification
Copyright
© 1970 Published by Elsevier Inc.
