Advertisement
Research Article| Volume 76, ISSUE 4, P560-568, October 1970

Download started.

Ok

Vascular reactivity and mechanical properties of normal and cadmium-hypertensive rabbits

  • Gurdarshan S. Thind
    Correspondence
    Reprint requests: Dr. G. S. Thind, Dept. of Medicine, The Graduate Hospital of University of Pennsylvania, 19th & Lombard Sts., Philadelphia, Pa. 19146.
    Affiliations
    From the Departments of Medicine and Surgery and Bockus Research Institute of the Graduate Hospital, University of Pennsylvania School of Medicine Philadelphia, Pa., USA
    Search for articles by this author
  • George Karreman
    Affiliations
    From the Departments of Medicine and Surgery and Bockus Research Institute of the Graduate Hospital, University of Pennsylvania School of Medicine Philadelphia, Pa., USA
    Search for articles by this author
  • Kathryn F. Stephan
    Affiliations
    From the Departments of Medicine and Surgery and Bockus Research Institute of the Graduate Hospital, University of Pennsylvania School of Medicine Philadelphia, Pa., USA
    Search for articles by this author
  • William S. Blakemore
    Affiliations
    From the Departments of Medicine and Surgery and Bockus Research Institute of the Graduate Hospital, University of Pennsylvania School of Medicine Philadelphia, Pa., USA
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0022214370902428
Vascular reactivity and mechanical properties of normal and cadmium-hypertensive rabbits
Previous ArticlePulmonary clearance of Pseudomonas aeruginosa
Next ArticleCerebral energy metabolism in short-chain fatty acid-induced coma
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Persistent hypertension was produced in 100 per cent of rabbits by weekly intraperitoneal injections of 2 mg. per kilogram of cadmium acetate. Growth and development of cadmium-hypertensive rabbits did not differ in any obvious way from that of control normotensive rabbits. Aortic wall thickness was normal, and there were no gross or histopathologic changes in cadmium-treated rabbits. Cadmium-hypertensive aortic strips developed a significantly lower passive tension on stepwise increase in strain (0 to 80 per cent) applied to the strips. Vascular reactivity of aortic strips obtained from the cadmium-hypertensive rabbits revealed a significantly decreased responsiveness to angiotensin but not to norepinephrine. Incubation in external cadmium (1.0 to 100.0 μg per milliliter of CdCl2) had no differential effect on the responses of control normotensive and cadmium-hypertensive aortic strips to either angiotensin or norepinephrine. It is suggested that the altered vascular reactivity and mechanical properties may be important in the pathophysiology of cadmium hypertension.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Schroeder H.A.
        • Kroll S.S.
        • Little J.W.
        • Livingston P.O.
        • Myers M.A.G.
        Hypertension in rats from injection of cadmium.
        Arch. Environ. Health. 1966; 13: 788
        • Schroeder H.A.
        • Nason A.P.
        • Prior R.E.
        • Reed J.B.
        • Haessler W.T.
        Influence of cadmium on renal ischemic hypertension in rats.
        Amer. J. Physiol. 1968; 214: 469
        • Schroeder H.A.
        • Nason A.P.
        • Mitchener M.
        Action of a chelate of zinc on trace metals in hypertensive rats.
        Amer. J. Physiol. 1968; 214: 796
        • Thind G.S.
        • Stephan K.F.
        • Blakemore W.S.
        Inhibition of vasopressor responses by cadmium.
        Amer. J. Physiol. 1970; 219: 577
        • Thind G.S.
        • Biery D.N.
        • Baum S.
        • Blakemore W.S.
        • Zinsser H.F.
        Blocking of vascular receptors by cadmium: A renal angiographic study.
        Circulation Suppl. 1969; 3: 202
        • Grant R.T.
        • Rothschild P.
        A device for estimating blood pressure in the rabbit.
        J. Physiol. 1934; 81: 265
        • Thind G.S.
        • Peterson L.H.
        • Zinsser H.F.
        A new simple and sensitive method for quantitative assay of angiotensin.
        Amer. J. Cardiol. 1967; 19: 153
        • Schroeder H.A.
        • Vinton Jr., W.H.
        • Balassa J.J.
        Effect of chromium, cadmium and other trace metals on the growth and survival of mice.
        Nutrition. 1963; 80: 39
        • Kanisawa M.
        • Schroeder H.A.
        Renal arteriolar sclerosis in hypertensive rats given cadmium in drinking water.
        Exp. and Molec. Path. 1969; 10: 81
        • Axelsson B.
        • Dahlgren S.E.
        • Piscator M.
        Renal lesions in the rabbit after long-term exposure to cadmium.
        Arch. Environ. Health. 1968; 17: 24
        • Baum J.
        • Worthen H.G.
        Induction of amyloid by cadmium.
        Nature. 1967; 213: 1040
        • Khairallah P.A.
        Vascular reactivity: experimental and clinical.
        in: Page I.H. McCubbin J.W. Renal hypertension. Year Book Medical Publishers, Inc, Chicago1968: 160-183
        • Kaplan N.M.
        • Silah J.G.
        The angiotensin-infusion test.
        New Eng. J. Med. 1964; 271: 536
        • Kaplan N.M.
        • Silah J.G.
        Effect of angiotensin II on blood pressure in humans with hypertensive disease.
        J. Clin. Invest. 1964; 43: 659
        • Silah J.G.
        • Strong C.G.
        • Nowaczynski W.
        • Genest J.W.
        The angiotensin-infusion test and peripheral venous renin activity.
        Canad. Med. Ass. J. 1967; 96: 1397
        • Scroop G.C.
        • Whelan R.F.
        Vascular reactivity studies in hypertension.
        Aust. J. Exp. Biol. Med. Sci. 1968; 46: 555
        • Feigl E.O.
        • Peterson L.H.
        • Jones A.W.
        Mechanical and chemical properties of arteries in experimental hypertension.
        J. Clin. Invest. 1963; 42: 1640
        • Jones A.W.
        • Feigl E.O.
        • Peterson L.H.
        Water and electrolyte content of normal and hypertensive arteries in dogs.
        Circulation Res. 1964; 15: 386
        • Tobian L.
        • Olson R.
        • Chesley G.
        Water content of arteriolar wall in renovascular hypertension.
        Amer. J. Physiol. 1969; 216: 22
        • Thind G.S.
        • Fischer G.M.
        • Blakemore W.S.
        Vascular reactivity and tissue cadmium concentrations in cadmium hypertension.
        Physiologist. 1970; 13: 320

      Article info

      Publication history

      Accepted: July 13, 1970
      Received: February 12, 1970

      Footnotes

      ☆Presented in part at the 53rd Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N. J., April 13 to 18, 1969, and published in Fed. Proc. 28: 329, 1969. (Abst.).

      ☆☆This investigation was supported in part by United States Public Health Service Grant HE-07762, N ONR 551 (54) and National Institutes of Health Grant No. 1-MO1-FR-00322.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214370902428

      Copyright

      © 1970 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX