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Abstract
Implantation of irradiated mouse spleens into the peritoneal cavity of mice did not
alter the number of hematopoietic stem cells in the femoral marrow when assayed by
the spleen colony method. On the other hand, there was a significantly greater number
of hematopoietic stem cells in femoral marrow of spleen-implanted mice as compared
to those in saline-treated mice 4 days after exposure to 200 r of x-irradiation (given
2 hours after spleen implants). Injections of homogenates made from spleens and of
a water-soluble fraction of this homogenate similarly resulted in an increase in the
rate of hematopoietic stem cell regeneration following 200 r. We postulate that a
noncellular substance of splenic origin can increase stem cell proliferation in mice.
Response to this stimulus is inhibited by the presence of a dense population of cells
in the environment.
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References
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Article info
Publication history
Accepted:
July 16,
1970
Received:
February 24,
1970
With the technical assistance of MAX DANSBIE and S. ARTHUR CONTIFootnotes
☆Studies reported here were supported by United States Public Health Service Grants CA04144-12 and AM12936-02 and grants from the Leukemia Research Foundation and the American Cancer Society.
Identification
Copyright
© 1970 Published by Elsevier Inc.
