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Abstract
Cornely's modification of the Boyden Chamber technique was used to detect the presence
of chemotactic activity. Chemotactic activity was found in the synovial fluid 60 to
90 min. after injection of synthetic monosodium urate crystals in the canine joint.
In comparison, no chemotactic activity was present in a saline-injected knee. Treatment
of animals with colchicine suppressed the generation of chemotactic activity. Further
studies will be necessary to determine whether these findings have applicability to
the understanding of human gouty arthritis.
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References
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Article info
Publication history
Accepted:
July 24,
1970
Received:
November 15,
1969
Footnotes
☆Supported by National Institutes of Health Grants AM-12593 and FR-107, and a Grant from the Eastern Pennsylvania Chapter of the Arthritis Foundation.
☆☆Presented in part at the Annual Meeting of the American Rheumatism Association, Boston, Mass., June, 1969.
Identification
Copyright
© 1970 Published by Elsevier Inc.