Research Article| Volume 76, ISSUE 4, P622-631, October 1970

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Appearance of chemotactic activity following intra-articular injection of monosodium urate crystals: Effect of colchicine

  • Paulding Phelps
    Reprint requests: Dr. Paulding Phelps, Philadelphia General Hospital, 34th and Civic Center Boulevard, Philadelphia, Pa. 19104.
    From the Rheumatology Research Laboratory, Philadelphia General Hospital, Philadelphia, Pa., USA

    From the Department of Medicine, University of Pennsylvania Philadelphia, Pa., USA
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      Cornely's modification of the Boyden Chamber technique was used to detect the presence of chemotactic activity. Chemotactic activity was found in the synovial fluid 60 to 90 min. after injection of synthetic monosodium urate crystals in the canine joint. In comparison, no chemotactic activity was present in a saline-injected knee. Treatment of animals with colchicine suppressed the generation of chemotactic activity. Further studies will be necessary to determine whether these findings have applicability to the understanding of human gouty arthritis.
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