Research Article| Volume 76, ISSUE 4, P641-651, October 1970

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The renal medulla as an antihypertensive organ

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      Transplantation of fragmented live histocompatible renal medulla (isografts) into hypertensive recipients caused a significant drop in arterial pressure; upon removal of these grafts the pressure returned to the hypertensive levels exhibited before the transplant. Fragmented live histocompatible renal cortex and fragmented dead (lyophilized) histocompatible renal medulla failed to lower the arterial pressure of hypertensive recipients. Fragmented, live incompatible renal medulla (allografts) dropped the arterial pressure of hypertensive recipients for 6 to 8 days; then the pressure returned to previous hypertensive levels while the tissue remained in situ. The rejection phenomena destroyed the tissue, and concomitantly the antihypertensive effect abated. Thus, the renal medulla appears to act as an antihypertensive organ.
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