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Endotoxin (S. typhosa) injected into mice 4 hours after injection of 150 mg. per kilogram of 5-fluorouracil (5-FU) enhanced their hematopoietic recovery. The accelerated regeneration after 5-FU was first demonstrable on Day 2 in the number of colony-forming units per femur, on Day 4 in the total nucleated marrow count, and on Day 6 in peripheral blood counts. Endotoxin injected 24 hours before 5-fluorouracil had the opposite effect. It delayed demonstrable regeneration of colony-forming units by 4 days and caused a severe and long-lasting granulocytopenia. It is concluded that endotoxin, either directly or indirectly, triggers normally resting colony-forming units into proliferative cycles.
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Accepted: July 31, 1970
Received: May 7, 1970
☆Supported by United States Public Health Service Grants AM07239 and CAO8736.
© 1970 Published by Elsevier Inc.