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Abstract
Endotoxin (S. typhosa) injected into mice 4 hours after injection of 150 mg. per kilogram of 5-fluorouracil
(5-FU) enhanced their hematopoietic recovery. The accelerated regeneration after 5-FU
was first demonstrable on Day 2 in the number of colony-forming units per femur, on
Day 4 in the total nucleated marrow count, and on Day 6 in peripheral blood counts.
Endotoxin injected 24 hours before 5-fluorouracil had the opposite effect. It delayed
demonstrable regeneration of colony-forming units by 4 days and caused a severe and
long-lasting granulocytopenia. It is concluded that endotoxin, either directly or
indirectly, triggers normally resting colony-forming units into proliferative cycles.
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Article info
Publication history
Accepted:
July 31,
1970
Received:
May 7,
1970
Footnotes
☆Supported by United States Public Health Service Grants AM07239 and CAO8736.
Identification
Copyright
© 1970 Published by Elsevier Inc.